Results 1 to 10 of about 859,409 (265)
A ubiquitination-mediated degradation system to target 14-3-3-binding phosphoproteins
Heliyon, 2023 The phosphorylation of 14-3-3 binding motif is involved in many cellular processes. A strategy that enables targeted degradation of 14-3-3-binding phosphoproteins (14-3-3-BPPs) for studying their functions is highly desirable for basic research. Here, we
Zhaokai Li +5 more
doaj +1 more source
Intra-aortic band impairs transapical device implantation in a pig: a case report
BMC Veterinary Research, 2023 Background Anatomic anomalies in the ascending aorta may impair the implantation and testing of cardiovascular devices in humans and animal models. Case presentation We present the rare case of an intra-aortic band in a German Landrace pig.
Florian Meissner +7 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2022 BackgroundDesmin is an intermediate filament protein that plays a critical role in the stabilization of the sarcomeres and cell contacts in the cardiac intercalated disk. Mutated DES gene can cause hereditary cardiomyopathy with heterogeneous phenotypes,
Yu-Xing Liu +9 more
doaj +1 more source
Cells, 2023 Cyclic nucleotide phosphodiesterases 2A (PDE2A) and PDE3A play an important role in the regulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-to-cAMP crosstalk. Each of these PDEs has up to three distinct isoforms.
Egor B. Skryabin +6 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2021 Objective: Inflammation plays important role in atherosclerotic cardiovascular diseases (CVDs), but the interaction between the inflammation and lipid profile is largely unrevealed in humans.
Yonghong Luo +6 more
doaj +1 more source
Frontiers in Immunology, 2020 Inflammation is one of the hallmarks of non-alcoholic steatohepatitis. CD47 is a widely expressed transmembrane protein that signals through inhibitory receptor signal regulatory protein α (SIRPα) to inhibit macrophage activation and phagocytosis.
Hui-Chao Tao +14 more
doaj +1 more source
Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia
Redox Biology, 2021 3′,5′-cyclic guanosine monophosphate (cGMP) is a druggable second messenger regulating cell growth and survival in a plethora of cells and disease states, many of which are associated with hypoxia. For example, in myocardial infarction and heart failure (
Nadja I. Bork +11 more
doaj +1 more source
Genomic, biochemical and expressional properties reveal strong conservation of the CLCA2 gene in birds and mammals [PDF]
PeerJ, 2022 Recent studies have revealed the dynamic and complex evolution of CLCA1 gene homologues in and between mammals and birds with a particularly high diversity in mammals.
Florian Bartenschlager +3 more
doaj +2 more sources
Frontiers in Cardiovascular Medicine, 2020 The position and morphology of human internal organs are asymmetrically distributed along the left–right axis. Aberrant left–right patterning in the developing embryo can lead to a series of congenital laterality defects, such as dextrocardia and ...
Zhuang-Zhuang Yuan +7 more
doaj +1 more source
Animal Models and Experimental Medicine, 2021 Heart transplantation is a lifesaving procedure, which is limited by the availability of donor hearts. Using hearts from donors after circulatory death, which have sustained global ischemia, requires thorough studies on reliable and reproducible models ...
Mohammed Quader +9 more
doaj +1 more source