Results 31 to 40 of about 8,229,123 (309)

Modelling the cardiovascular system

Critical Care and Resuscitation, 2007
Cardiovascular disease claims more lives than any other disease in westernised countries, affecting millions. Pinpointing cardiovascular system dysfunction is often difficult because the clinical signs, or the availability and interpretation of physiological measurements, are unreliable. Often patient-specific information is incomplete or confusing, as
Shaw, G. M., Chase, J. G., Starfinger, C., Smith, B., Hann, C. E., Desaive, Thomas, Ghuysen, Alexandre   +6 more
openaire   +3 more sources

A Novel Nonsense MMP21 Variant Causes Dextrocardia and Congenital Heart Disease in a Han Chinese Patient

Frontiers in Cardiovascular Medicine, 2020
The position and morphology of human internal organs are asymmetrically distributed along the left–right axis. Aberrant left–right patterning in the developing embryo can lead to a series of congenital laterality defects, such as dextrocardia and ...
Zhuang-Zhuang Yuan, Zhuang-Zhuang Yuan, Zhuang-Zhuang Yuan, Liang-Liang Fan, Liang-Liang Fan, Zi-Chen Jiang, Yi-Feng Yang, Zhi-Ping Tan   +7 more
doaj   +1 more source

Refining murine heterotopic heart transplantation: A model to study ischemia and reperfusion injury in donation after circulatory death hearts

Animal Models and Experimental Medicine, 2021
Heart transplantation is a lifesaving procedure, which is limited by the availability of donor hearts. Using hearts from donors after circulatory death, which have sustained global ischemia, requires thorough studies on reliable and reproducible models ...
Mohammed Quader, Renee Cholyway, Niluka Wickramaratne, Oluwatoyin Akande, Martin Mangino, Eleonora Mezzaroma, Adolfo G. Mauro, Qun Chen, Alexander Kantlis, Stefano Toldo   +9 more
doaj   +1 more source

Modelling the cardiovascular effects of ephedrine [PDF]

British Journal of Clinical Pharmacology, 2004
Aims  Recent reports have called into question the safety of ephedra supplements especially with regards to their cardiovascular effects. The purpose of this analysis was to characterize, via pharmacokinetic/pharmacodynamic modelling, the cardiovascular effects of ephedrine, the main active ingredient of ephedra, in apparently healthy, overweight ...
Adam M, Persky, N Seth, Berry, Gary M, Pollack, Kim L R, Brouwer   +3 more
openaire   +2 more sources

Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice

Journal of Lipid Research, 2009
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is predominantly expressed in liver and regulates cholesterol metabolism by down regulating liver LDL receptor (LDLR) proteins.
Yi Luo, Laurie Warren, Donghui Xia, Heather Jensen, Thomas Sand, Stephen Petras, Wenning Qin, Kenneth S. Miller, Julie Hawkins   +8 more
doaj   +1 more source

Plasma lipidomic signatures of spontaneous obese rhesus monkeys

Lipids in Health and Disease, 2019
Background Obesity plays crucial roles in the pathogenesis of metabolic diseases such as hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes (T2D).
Junlong Wang, Linqiang Zhang, Ruyue Xiao, Yunhai Li, Shasha Liao, Zhiguo Zhang, Wenhui Yang, Bin Liang   +7 more
doaj   +1 more source

Exploring ethnic inequalities in cardiovascular disease using Hospital Episode Statistics [PDF]

, 2009
This thesis is based on a population study conducted to explore ethnic inequalities in cardiovascular disease using Hospital Episode Statistics (HES). The Hospital Episode Statistics have significant potential for health studies for ethnic groups, due to
Liu, Lixun
core   +2 more sources

Imaging in population science: cardiovascular magnetic resonance in 100,000 participants of UK Biobank - rationale, challenges and approaches. [PDF]

, 2013
UK Biobank is a prospective cohort study with 500,000 participants aged 40 to 69. Recently an enhanced imaging study received funding. Cardiovascular magnetic resonance (CMR) will be part of a multi-organ, multi-modality imaging visit in 3-4 dedicated UK
Frank E Rademakers, Steffen E Petersen, Petersen, SE, Rademakers, Frank E., Neubauer, Stefan, Nagel, E, Peakman, T, Sellors, J, Peakman, Tim, Petersen, Steffen E., Rademakers, Frank E, Rademakers, FE, Paul Leeson, Nagel, Eike, Matthews, PM, Young, AA, Tim Peakman, Fabian Bamberg, Plein, S, Friedrich, MG, Young, Alistair A, Young, Alistair, Steve Garratt, Jane M Francis, Sven Plein, Francis, Jane M., Rory Collins, Friedrich, Matthias G, Plein, Sven, Bluemke, David A., Young, Alistair A., Alistair A Young, Jonathan Sellors, Collins, Rory, Leeson, Paul, Francis, JM, Bamberg, F, David A Bluemke, Collins, R, Francis, Jane M, Garratt, Steve, Paul M Matthews, Bluemke, David A, Matthews, Paul M, Matthias G Friedrich, Friedrich, Matthias G., Sellors, Jonathan, Bluemke, DA, Garratt, S, Matthews, Paul M., Neubauer, S, Bamberg, Fabian, Petersen, Steffen E, Eike Nagel, Stefan Neubauer, Leeson, P   +55 more
core   +1 more source

Association of Mental Health-Related Proteins DAXX, DRD3, and DISC1 With the Progression and Prognosis of Chondrosarcoma

Frontiers in Molecular Biosciences, 2019
Chondrosarcoma is the second most common malignant bone tumor. Current therapies remain ineffective, resulting in poor prognoses. Biomarkers for chondrosarcoma and predictors of its prognosis have not been established. Mental health–related proteins have
Lile He, Lile He, Xiangyu Shi, Ruiqi Chen, Ruiqi Chen, Zhengchun Wu, Zhulin Yang, Zhihong Li, Zhihong Li   +8 more
doaj   +1 more source

Multifaceted Functions and Novel Insight Into the Regulatory Role of RNA N6-Methyladenosine Modification in Musculoskeletal Disorders

Frontiers in Cell and Developmental Biology, 2020
RNA modifications have emerged as key regulators of transcript expression in diverse physiological and pathological processes. As one of the most prevalent types of RNA modifications, N6-methyladenosine (m6A) has become the highlight in modulation of ...
Wenchao Zhang, Wenchao Zhang, Lile He, Lile He, Zhongyue Liu, Zhongyue Liu, Xiaolei Ren, Xiaolei Ren, Lin Qi, Lin Qi, Lu Wan, Lu Wan, Wanchun Wang, Wanchun Wang, Chao Tu, Chao Tu, Zhihong Li, Zhihong Li   +17 more
doaj   +1 more source