Results 31 to 40 of about 859,409 (265)

Multifaceted Functions and Novel Insight Into the Regulatory Role of RNA N6-Methyladenosine Modification in Musculoskeletal Disorders

Frontiers in Cell and Developmental Biology, 2020
RNA modifications have emerged as key regulators of transcript expression in diverse physiological and pathological processes. As one of the most prevalent types of RNA modifications, N6-methyladenosine (m6A) has become the highlight in modulation of ...
Wenchao Zhang, Wenchao Zhang, Lile He, Lile He, Zhongyue Liu, Zhongyue Liu, Xiaolei Ren, Xiaolei Ren, Lin Qi, Lin Qi, Lu Wan, Lu Wan, Wanchun Wang, Wanchun Wang, Chao Tu, Chao Tu, Zhihong Li, Zhihong Li   +17 more
doaj   +1 more source

Sex differences in risk factors for cardiovascular disease: the PERU MIGRANT study. [PDF]

, 2012
INTRODUCTION: Although men and women have similar risk factors for cardiovascular disease, many social behaviors in developing countries differ by sex. Rural-to-urban migrants have different cardiovascular risk profiles than rural or urban dwellers.
Bernabe-Ortiz Antonio, Gilman Robert H., Smeeth Liam, Benziger Catherine Pastorius, Miranda J. Jaime, Gilman, Robert H, Catherine Pastorius Benziger, Liam Smeeth, Catherine Pastorius Benziger (172968), Robert H. Gilman (43897), Liam Smeeth (67156), Antonio Bernabe-Ortiz (90790), Antonio Bernabe-Ortiz, Smeeth, Liam, Miranda, J Jaime, Bernabe-Ortiz, Antonio, Robert H Gilman, J Jaime Miranda, Benziger, Catherine Pastorius, J. Jaime Miranda (5649565)   +19 more
core   +1 more source

Pharmacogenomics of Cardiovascular Pharmacology: Pharmacogenomic Network of Cardiovascular Disease Models

Journal of Pharmacological Sciences, 2008
The most important strategies in pharmacogenomics are gene expression profiling and the network analysis of human disease models. We have previously discovered novel drug target candidates in cardiovascular diseases through investigations of these ...
Toshio Tanaka, Takehiko Oka, Yasuhito Shimada, Noriko Umemoto, Junya Kuroyanagi, Chikara Sakamoto, Liqing Zang, Zhipeng Wang, Yuhei Nishimura   +8 more
doaj   +1 more source

CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells

Frontiers in Physiology, 2021
A deficiency in cystic fibrosis transmembrane conductance regulator (CFTR) function in CF leads to chronic lung disease. CF is associated with abnormalities in fatty acids, ceramides, and cholesterol, their relationship with CF lung pathology is not ...
Mieke Veltman, Mieke Veltman, Juan B. De Sanctis, Marta Stolarczyk, Nikolai Klymiuk, Nikolai Klymiuk, Andrea Bähr, Andrea Bähr, Rutger W. Brouwer, Rutger W. Brouwer, Edwin Oole, Edwin Oole, Juhi Shah, Tomas Ozdian, Jie Liao, Carolina Martini, Danuta Radzioch, John W. Hanrahan, John W. Hanrahan, Bob J. Scholte, Bob J. Scholte   +20 more
doaj   +1 more source

What Genetic Modifications of Source Pigs Are Essential and Sufficient for Cell, Tissue, and Organ Xenotransplantation?

Transplant International
Xenotransplantation of porcine organs has made remarkable progress towards clinical application. A key factor has been the generation of genetically multi-modified source pigs for xenotransplants, protected against immune rejection and coagulation ...
Asghar Ali, Asghar Ali, Mayuko Kurome, Mayuko Kurome, Barbara Kessler, Barbara Kessler, Elisabeth Kemter, Elisabeth Kemter, Elisabeth Kemter, Elisabeth Kemter, Eckhard Wolf, Eckhard Wolf, Eckhard Wolf, Eckhard Wolf   +13 more
doaj   +1 more source

The efficiency of cardiovascular risk assessment: do the right patients get statin treatment? [PDF]

, 2013
OBJECTIVE: To evaluate targeting of statin prescribing for primary prevention to those with high cardiovascular disease (CVD) risk. DESIGN: Two cohort studies including the general population and initiators of statins aged 35-74 years.
Van Staa, Tjeerd; id_orcid, van Staa, Tjeerd-Pieter, Gulliford, Martin, Goldacre, Ben, Smeeth, Liam, Ng, Edmond S-W   +5 more
core   +1 more source

Usage of PCI and long-term cardiovascular risk in post-myocardial infarction patients: a nationwide registry cohort study from Finland [PDF]

, 2022
Background: Despite currently available treatments, the burden of myocardial infarction (MI) morbidity and mortality remains prominent. The aim of this was to investigate the risk of developing subsequent cardiovascular events in MI patients.Methods ...
Airaksinen J., Prami T., Hasvold P., Reissell E., Kytö V., Khanfir H.   +5 more
core   +1 more source

Modeling risks of cardiovascular and cancer mortality following a diagnosis of loco-regional breast cancer

Breast Cancer Research, 2021
Background Many women with breast cancer also have a high likelihood of cardiovascular mortality, and while there are several cardiovascular risk prediction models, none have been validated in a cohort of breast cancer patients.
Nicole M. Leoce, Zhezhen Jin, Rebecca D. Kehm, Janise M. Roh, Cecile A. Laurent, Lawrence H. Kushi, Mary Beth Terry   +6 more
doaj   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Comparative performance of cardiovascular risk prediction models in people living with HIV

, 2022
BACKGROUND: Current cardiovascular risk assessment in people living with HIV is based on general risk assessment tools; however, whether these tools can be applied in sub-Saharan African populations has been questioned.
Vos, A.G., Grobbee, D.E., Barth, Roos E., Tempelman, Hugo A., Venter, W.D.F., Damen, J.A.A., Barth, Roos, Barth, R.E., Tempelman, H.A., Damen, Johanna, Venter, Willem, Tahir, I.S., Tahir, Irtiza S., Scheuermaier, K., Grobbee, Diederick, Scheuermaier, Karine, Tahir, Irtiza, Vos, Alinda G., Vos, Alinda, Damen, Johanna A.A., Klipstein-Grobusch, Kerstin, Klipstein-Grobusch, K., Grobbee, Diederick E., Tempelman, Hugo, Venter, Willem D.F.   +24 more
core   +1 more source