Results 21 to 30 of about 8,229,123 (309)

CD47 Deficiency in Mice Exacerbates Chronic Fatty Diet-Induced Steatohepatitis Through Its Role in Regulating Hepatic Inflammation and Lipid Metabolism

open access: yesFrontiers in Immunology, 2020
Inflammation is one of the hallmarks of non-alcoholic steatohepatitis. CD47 is a widely expressed transmembrane protein that signals through inhibitory receptor signal regulatory protein α (SIRPα) to inhibit macrophage activation and phagocytosis.
Hui-Chao Tao   +14 more
doaj   +1 more source

Structural modelling of the cardiovascular system [PDF]

open access: yesBiomechanics and Modeling in Mechanobiology, 2018
Computational modelling of the cardiovascular system offers much promise, but represents a truly interdisciplinary challenge, requiring knowledge of physiology, mechanics of materials, fluid dynamics and biochemistry. This paper aims to provide a summary of the recent advances in cardiovascular structural modelling, including the numerical methods ...
Benjamin Owen   +4 more
openaire   +2 more sources

Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia

open access: yesRedox Biology, 2021
3′,5′-cyclic guanosine monophosphate (cGMP) is a druggable second messenger regulating cell growth and survival in a plethora of cells and disease states, many of which are associated with hypoxia. For example, in myocardial infarction and heart failure (
Nadja I. Bork   +11 more
doaj   +1 more source

Genomic, biochemical and expressional properties reveal strong conservation of the CLCA2 gene in birds and mammals [PDF]

open access: yesPeerJ, 2022
Recent studies have revealed the dynamic and complex evolution of CLCA1 gene homologues in and between mammals and birds with a particularly high diversity in mammals.
Florian Bartenschlager   +3 more
doaj   +2 more sources

Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies [PDF]

open access: yes, 2011
BACKGROUND: Guidelines differ about the value of assessment of adiposity measures for cardiovascular disease risk prediction when information is available for other risk factors. We studied the separate and combined associations of body-mass index (BMI),
Nordestgaard, Borge G.   +77 more
core   +1 more source

Editorial: Insights in cardiovascular therapeutics: 2021 – cell death, cardiovascular injuries, and novel targets of cardiovascular therapeutics

open access: yes, 2022
With the effort and support of the authors, editorial office, and editorial team, the Frontiers in Cardiovascular Medicine, Cardiovascular Therapeutics Section-Research Topic “Insights in Cardiovascular Therapeutics: 2021” has achieved great success and ...
Vazquez-Padron, Roberto I.   +13 more
core   +1 more source

Circulating progenitor cell count for cardiovascular risk stratification: a pooled analysis [PDF]

open access: yes, 2010
Background: Circulating progenitor cells (CPC) contribute to the homeostasis of the vessel wall, and a reduced CPC count predicts cardiovascular morbidity and mortality.
Zeiher Andreas M.   +46 more
core   +2 more sources

Data for cardiovascular modeling

open access: yesJournal of the American College of Cardiology, 1989
Data are required for a meaningful approach to quality and cost-conscious cardiovascular care. How to identify the types of data available and their sources, advantages and limitations to their use, issues involved in combining data from different sources for decision modeling and some possible solutions are discussed in this summary of the Working ...
Muhlbaier, Lawrence H., Pryor, David B.
openaire   +2 more sources

Roadmap for cardiovascular circulation model [PDF]

open access: yesThe Journal of Physiology, 2016
AbstractComputational models of many aspects of the mammalian cardiovascular circulation have been developed. Indeed, along with orthopaedics, this area of physiology is one that has attracted much interest from engineers, presumably because the equations governing blood flow in the vascular system are well understood and can be solved with well ...
Soroush Safaei   +14 more
openaire   +2 more sources

C-Reactive Protein, Fibrinogen, and Cardiovascular Disease Prediction [PDF]

open access: yes, 2012
BACKGROUND: There is debate about the value of assessing levels of C-reactive protein (CRP) and other biomarkers of inflammation for the prediction of first cardiovascular events.
Iso, Hiroyasu   +440 more
core   +3 more sources

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