Results 21 to 30 of about 812,277 (267)

Association of Mental Health-Related Proteins DAXX, DRD3, and DISC1 With the Progression and Prognosis of Chondrosarcoma

Frontiers in Molecular Biosciences, 2019
Chondrosarcoma is the second most common malignant bone tumor. Current therapies remain ineffective, resulting in poor prognoses. Biomarkers for chondrosarcoma and predictors of its prognosis have not been established. Mental health–related proteins have
Lile He, Lile He, Xiangyu Shi, Ruiqi Chen, Ruiqi Chen, Zhengchun Wu, Zhulin Yang, Zhihong Li, Zhihong Li   +8 more
doaj   +1 more source

Multifaceted Functions and Novel Insight Into the Regulatory Role of RNA N6-Methyladenosine Modification in Musculoskeletal Disorders

Frontiers in Cell and Developmental Biology, 2020
RNA modifications have emerged as key regulators of transcript expression in diverse physiological and pathological processes. As one of the most prevalent types of RNA modifications, N6-methyladenosine (m6A) has become the highlight in modulation of ...
Wenchao Zhang, Wenchao Zhang, Lile He, Lile He, Zhongyue Liu, Zhongyue Liu, Xiaolei Ren, Xiaolei Ren, Lin Qi, Lin Qi, Lu Wan, Lu Wan, Wanchun Wang, Wanchun Wang, Chao Tu, Chao Tu, Zhihong Li, Zhihong Li   +17 more
doaj   +1 more source

Zebrafish Models of Cancer Therapy-Induced Cardiovascular Toxicity

Journal of Cardiovascular Development and Disease, 2021
Purpose of review: Both traditional and novel cancer therapies can cause cardiovascular toxicity in patients. In vivo models integrating both cardiovascular and cancer phenotypes allow for the study of on- and off-target mechanisms of toxicity arising ...
Sarah Lane, Luis Alberto More, Aarti Asnani   +2 more
doaj   +1 more source

Experimental Rodent Models of Cardiovascular Diseases

Frontiers in Cardiovascular Medicine, 2020
Cardiovascular diseases, as the most common non-communicable disease in the world, cause a high mortality rate today and bring a serious medical burden to countries worldwide, especially in low- and middle-income countries. Experimental rodent models are
Tian Jia, Chen Wang, Zhengxi Han, Xiaozhi Wang, Ming Ding, Quanyi Wang   +5 more
doaj   +1 more source

A method to construct a points system to predict cardiovascular disease considering repeated measures of risk factors [PDF]

PeerJ, 2016
Current predictive models for cardiovascular disease based on points systems use the baseline situation of the risk factors as independent variables. These models do not take into account the variability of the risk factors over time.
Antonio Palazón-Bru, Julio Antonio Carbayo-Herencia, Maria Isabel Vigo, Vicente Francisco Gil-Guillén   +3 more
doaj   +2 more sources

Cardiovascular Risk Prediction in Men and Women Aged Under 50 Years Using Routine Care Data

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Prediction models for risk of cardiovascular events generally do not include young adults, and cardiovascular risk factors differ between women and men.
Hendrikus J. A. van Os, Jos P. Kanning, Tobias N. Bonten, Margot M. Rakers, Hein Putter, Mattijs E. Numans, Ynte M. Ruigrok, Rolf H. H. Groenwold, Marieke J. H. Wermer   +8 more
doaj   +1 more source

Modelling the cardiovascular effects of ephedrine [PDF]

British Journal of Clinical Pharmacology, 2004
Aims  Recent reports have called into question the safety of ephedra supplements especially with regards to their cardiovascular effects. The purpose of this analysis was to characterize, via pharmacokinetic/pharmacodynamic modelling, the cardiovascular effects of ephedrine, the main active ingredient of ephedra, in apparently healthy, overweight ...
Adam M, Persky, N Seth, Berry, Gary M, Pollack, Kim L R, Brouwer   +3 more
openaire   +2 more sources

Pharmacogenomics of Cardiovascular Pharmacology: Pharmacogenomic Network of Cardiovascular Disease Models

Journal of Pharmacological Sciences, 2008
The most important strategies in pharmacogenomics are gene expression profiling and the network analysis of human disease models. We have previously discovered novel drug target candidates in cardiovascular diseases through investigations of these ...
Toshio Tanaka, Takehiko Oka, Yasuhito Shimada, Noriko Umemoto, Junya Kuroyanagi, Chikara Sakamoto, Liqing Zang, Zhipeng Wang, Yuhei Nishimura   +8 more
doaj   +1 more source

CFTR Correctors and Antioxidants Partially Normalize Lipid Imbalance but not Abnormal Basal Inflammatory Cytokine Profile in CF Bronchial Epithelial Cells

Frontiers in Physiology, 2021
A deficiency in cystic fibrosis transmembrane conductance regulator (CFTR) function in CF leads to chronic lung disease. CF is associated with abnormalities in fatty acids, ceramides, and cholesterol, their relationship with CF lung pathology is not ...
Mieke Veltman, Mieke Veltman, Juan B. De Sanctis, Marta Stolarczyk, Nikolai Klymiuk, Nikolai Klymiuk, Andrea Bähr, Andrea Bähr, Rutger W. Brouwer, Rutger W. Brouwer, Edwin Oole, Edwin Oole, Juhi Shah, Tomas Ozdian, Jie Liao, Carolina Martini, Danuta Radzioch, John W. Hanrahan, John W. Hanrahan, Bob J. Scholte, Bob J. Scholte   +20 more
doaj   +1 more source

What Genetic Modifications of Source Pigs Are Essential and Sufficient for Cell, Tissue, and Organ Xenotransplantation?

Transplant International
Xenotransplantation of porcine organs has made remarkable progress towards clinical application. A key factor has been the generation of genetically multi-modified source pigs for xenotransplants, protected against immune rejection and coagulation ...
Asghar Ali, Asghar Ali, Mayuko Kurome, Mayuko Kurome, Barbara Kessler, Barbara Kessler, Elisabeth Kemter, Elisabeth Kemter, Elisabeth Kemter, Elisabeth Kemter, Eckhard Wolf, Eckhard Wolf, Eckhard Wolf, Eckhard Wolf   +13 more
doaj   +1 more source