Results 21 to 30 of about 859,409 (265)

Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice

Journal of Lipid Research, 2009
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is predominantly expressed in liver and regulates cholesterol metabolism by down regulating liver LDL receptor (LDLR) proteins.
Yi Luo, Laurie Warren, Donghui Xia, Heather Jensen, Thomas Sand, Stephen Petras, Wenning Qin, Kenneth S. Miller, Julie Hawkins   +8 more
doaj   +1 more source

The genetics of cardiovascular disease [PDF]

, 2008
Recent advances in genotyping technology and insights into disease mechanisms have increased interest in the genetics of cardiovascular disease. Several candidate genes involved in cardiovascular diseases were identified from studies using animal models,
Padmanabhan, S., Delles, C., Dominiczak, A.F., McBride, M.W.   +3 more
core   +1 more source

Plasma lipidomic signatures of spontaneous obese rhesus monkeys

Lipids in Health and Disease, 2019
Background Obesity plays crucial roles in the pathogenesis of metabolic diseases such as hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes (T2D).
Junlong Wang, Linqiang Zhang, Ruyue Xiao, Yunhai Li, Shasha Liao, Zhiguo Zhang, Wenhui Yang, Bin Liang   +7 more
doaj   +1 more source

Prospective validation and assessment of cardiovascular and offspring risk models for pregnant women with congenital heart disease [PDF]

, 2014
OBJECTIVES: Adequate prepregnancy prediction of maternal cardiovascular and offspring risk is important for counselling and management of pregnancy in women with congenital heart disease (CHD).
Sollie-Szarynska, Krystyna M., Wajon, EMCJ, Hillege, Hans L., Mulder, B.J., Ruys, T.P., Ruys, T.P.E., van Dijk, Arie P. J., Veldhuisen, D.J. van, Pieper, P.G., Aarnoudse, Jan G., Ruys, Titia P.E., Bijl, A.G. van der, Bijl, A.G.L. van der, Vliegen, Hubert W., Mulder, B.J.M., Aarnoudse, JG, Aarnoudse, J.G., Hillege, H.L., Vliegen, H.W., ZAHARA 2 Investigators, Dijk, A.P.J. van, Drenthen, W, Mulder, Barbara J.M., Pieper, Petronella G., Sollie-Szarynska, K.M., Wajon, E.M.C.J., Mulder, Barbara J. M., Roos-Hesselink, Jolien W., Wajon, Elly M.C.J., Drenthen, Willem; id_orcid, Sollie-Szarynska, KM, Mulder, BJM, Roos-Hesselink, J.W., Van Dijk, Arie P.J., Pieper, PG, Ruys, Titia, Balci, Ali, van Veldhuisen, Dirk J., Balci, A, Roos - Hesselink, Jolien, Wajon, Elly M. C. J., van der Bijl, AGL, Drenthen, W., Van Der Bijl, Antoinette G.L., Ruys, Titia P. E., Hillege, HL, van Dijk, APJ, van der Bijl, Antoinette G. L., Vliegen, HW, Balci, A., Wajon, E.M., Drenthen, Willem, Veldhuisen, DJ   +52 more
core   +1 more source

Cardiovascular risk profile and frailty in a population-based study of older British men. [PDF]

, 2015
Frailty in older age is known to be associated with cardiovascular disease (CVD) risk. However, the extent to which frailty is associated with the CVD risk profile has been little studied.
Papacosta, AO, Arianayagam, DS, Whincup, PH, Ramsay, SE, Iliffe, S, Lennon, LT, Cryer, J, Wannamethee, SG   +7 more
core   +1 more source

Experimental Rodent Models of Cardiovascular Diseases

Frontiers in Cardiovascular Medicine, 2020
Cardiovascular diseases, as the most common non-communicable disease in the world, cause a high mortality rate today and bring a serious medical burden to countries worldwide, especially in low- and middle-income countries. Experimental rodent models are
Tian Jia, Chen Wang, Zhengxi Han, Xiaozhi Wang, Ming Ding, Quanyi Wang   +5 more
doaj   +1 more source

Zebrafish Models of Cancer Therapy-Induced Cardiovascular Toxicity

Journal of Cardiovascular Development and Disease, 2021
Purpose of review: Both traditional and novel cancer therapies can cause cardiovascular toxicity in patients. In vivo models integrating both cardiovascular and cancer phenotypes allow for the study of on- and off-target mechanisms of toxicity arising ...
Sarah Lane, Luis Alberto More, Aarti Asnani   +2 more
doaj   +1 more source

Association of Mental Health-Related Proteins DAXX, DRD3, and DISC1 With the Progression and Prognosis of Chondrosarcoma

Frontiers in Molecular Biosciences, 2019
Chondrosarcoma is the second most common malignant bone tumor. Current therapies remain ineffective, resulting in poor prognoses. Biomarkers for chondrosarcoma and predictors of its prognosis have not been established. Mental health–related proteins have
Lile He, Lile He, Xiangyu Shi, Ruiqi Chen, Ruiqi Chen, Zhengchun Wu, Zhulin Yang, Zhihong Li, Zhihong Li   +8 more
doaj   +1 more source

Cardiovascular Risk Prediction in Men and Women Aged Under 50 Years Using Routine Care Data

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Prediction models for risk of cardiovascular events generally do not include young adults, and cardiovascular risk factors differ between women and men.
Hendrikus J. A. van Os, Jos P. Kanning, Tobias N. Bonten, Margot M. Rakers, Hein Putter, Mattijs E. Numans, Ynte M. Ruigrok, Rolf H. H. Groenwold, Marieke J. H. Wermer   +8 more
doaj   +1 more source

A method to construct a points system to predict cardiovascular disease considering repeated measures of risk factors [PDF]

PeerJ, 2016
Current predictive models for cardiovascular disease based on points systems use the baseline situation of the risk factors as independent variables. These models do not take into account the variability of the risk factors over time.
Antonio Palazón-Bru, Julio Antonio Carbayo-Herencia, Maria Isabel Vigo, Vicente Francisco Gil-Guillén   +3 more
doaj   +2 more sources