Results 11 to 20 of about 8,229,123 (309)

Animal Models of Cardiovascular Diseases [PDF]

BioMed Research International, 2011
Cardiovascular diseases are the first leading cause of death and morbidity in developed countries. The use of animal models have contributed to increase our knowledge, providing new approaches focused to improve the diagnostic and the treatment of these pathologies.
Zaragoza, Carlos, Gomez-Guerrero, Carmen, Martin-Ventura, Jose Luis, Blanco-Colio, Luis, Lavín Plaza, Begoña, Mallavia, Beñat, Tarin, Carlos, Mas, Sebastian, Ortiz, Alberto, Egido, Jesus   +9 more
openaire   +5 more sources

In Vitro Models of Cardiovascular Calcification

Biomedicines
Cardiovascular calcification, characterized by hydroxyapatite deposition in the arterial wall and heart valves, is associated with high cardiovascular morbidity and mortality.
Andrea Tóth, Enikő Balogh, Viktória Jeney   +2 more
doaj   +3 more sources

Lumped-Parameter Modelling of Cardiovascular System Dynamics under Different Healthy and Diseased Conditions [PDF]

, 2013
Cardiovascular disease is the most common cause of death in the modern society, and research into the diagnosis and treatment of cardiovascular diseases is an urgent task.
Shi, Yubing
core   +6 more sources

A ubiquitination-mediated degradation system to target 14-3-3-binding phosphoproteins

Heliyon, 2023
The phosphorylation of 14-3-3 binding motif is involved in many cellular processes. A strategy that enables targeted degradation of 14-3-3-binding phosphoproteins (14-3-3-BPPs) for studying their functions is highly desirable for basic research. Here, we
Zhaokai Li, Xiaoqiang Huang, Mohan Li, Y. Eugene Chen, Zhong Wang, Liu Liu   +5 more
doaj   +1 more source

Intra-aortic band impairs transapical device implantation in a pig: a case report

BMC Veterinary Research, 2023
Background Anatomic anomalies in the ascending aorta may impair the implantation and testing of cardiovascular devices in humans and animal models. Case presentation We present the rare case of an intra-aortic band in a German Landrace pig.
Florian Meissner, Michelle Costa Galbas, Johannes Dinkelaker, Heidi Cristina Schmitz, Hendrik Straky, Johanna Reuter, Martin Czerny, Wolfgang Bothe   +7 more
doaj   +1 more source

Case report: Whole-exome sequencing identifies a novel DES mutation (p. E434K) in a Chinese family with cardiomyopathy and sudden cardiac death

Frontiers in Cardiovascular Medicine, 2022
BackgroundDesmin is an intermediate filament protein that plays a critical role in the stabilization of the sarcomeres and cell contacts in the cardiac intercalated disk. Mutated DES gene can cause hereditary cardiomyopathy with heterogeneous phenotypes,
Yu-Xing Liu, Yu-Xing Liu, Yu-Xing Liu, Rong Yu, Yue Sheng, Yue Sheng, Liang-Liang Fan, Liang-Liang Fan, Liang-Liang Fan, Yao Deng   +9 more
doaj   +1 more source

Cardiovascular System Modeling [PDF]

Computational and Mathematical Methods in Medicine, 2012
Mathematical models and numerical simulations of the cardiovascular system are very useful for understanding the mechanisms influencing its function and its physiological and pathological processes. This modeling research increases the potential for developing new diagnostic and therapeutic cardiovascular techniques or devices and is also helpful for ...
Ling Xia 0001, Alan Murray, Dingchang Zheng, Feng Liu 0005, Xuesong Ye, Gangmin Ning   +5 more
openaire   +6 more sources

CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms

Cells, 2023
Cyclic nucleotide phosphodiesterases 2A (PDE2A) and PDE3A play an important role in the regulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-to-cAMP crosstalk. Each of these PDEs has up to three distinct isoforms.
Egor B. Skryabin, Kirstie A. De Jong, Hariharan Subramanian, Nadja I. Bork, Alexander Froese, Boris V. Skryabin, Viacheslav O. Nikolaev   +6 more
doaj   +1 more source

Preclinical Models of Cancer Therapy-Associated Cardiovascular Toxicity: A Scientific Statement From the American Heart Association [PDF]

, 2021
Although cardiovascular toxicity from traditional chemotherapies has been well recognized for decades, the recent explosion of effective novel targeted cancer therapies with cardiovascular sequelae has driven the emergence of cardio-oncology as a new ...
Grumbach, Isabella, Moslehi, Javid, Ghigo, Alessandra, Baik, Alan, de Boer, Rudolf A., Beyer, Andreas, Zhu, Han, Asnani, Aarti, Beyer, Andreas M., Jain, Salvia, Baik, Alan H., Adhikari, Bishow, Grumbach, Isabella M., Moslehi, Javid J., Adhikari, Bishow B., de Boer, Rudolf   +15 more
core   +2 more sources

Improvements in High-Density Lipoprotein Quantity and Quality Contribute to the Cardiovascular Benefits by Anti-tumor Necrosis Factor Therapies in Rheumatoid Arthritis: A Systemic Review and Meta-Analysis

Frontiers in Cardiovascular Medicine, 2021
Objective: Inflammation plays important role in atherosclerotic cardiovascular diseases (CVDs), but the interaction between the inflammation and lipid profile is largely unrevealed in humans.
Yonghong Luo, Xiaolei Ren, Xiaolei Ren, Shuwei Weng, Chunhui Yan, Qiaoxia Mao, Daoquan Peng   +6 more
doaj   +1 more source