Results 41 to 50 of about 812,277 (267)

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Protocol for in vivo analysis of muscle function in porcine models for muscular dystrophies

STAR Protocols
Summary: Porcine models carrying DMD mutations recapitulate Duchenne and Becker muscular dystrophy (DMD and BMD), inherited disorders leading to progressive muscle weakness, with DMD presenting a far more severe and rapidly progressive phenotype ...
Hristiyan Hristov, Michaela Blasi, Igor Neves Barbosa, Elisabeth Kemter, Mayuko Kurome, Barbara Kessler, Valeri Zakhartchenko, Nikolai Klymiuk, Michael Stirm, Florian Jaudas, Eckhard Wolf   +10 more
doaj   +1 more source

Cardiovascular Tissue Engineering Models for Atherosclerosis Treatment Development

Bioengineering, 2023
In the early years of tissue engineering, scientists focused on the generation of healthy-like tissues and organs to replace diseased tissue areas with the aim of filling the gap between organ demands and actual organ donations.
Linnea Tscheuschner, Abraham R. Tzafriri
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Worldwide variation in cardiovascular magnetic resonance practice models

Journal of Cardiovascular Magnetic Resonance, 2023
Introduction The use of cardiovascular magnetic resonance (CMR) for diagnosis and management of a broad range of cardiac and vascular conditions has quickly expanded worldwide. It is essential to understand how CMR is utilized in different regions around
Lilia M. Sierra-Galan, Edgar E. S. Estrada-Lopez, Victor A. Ferrari, Subha V. Raman, Vanessa M. Ferreira, Vimaj Raj, Elizabeth Joseph, Jeanette Schulz-Menger, Carmen W. S. Chan, Sylvia S. M. Chen, Yuchen Cheng, Juliano De Lara Fernandez, Masahiro Terashima, Timothy S. E. Albert   +13 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Cardiovascular Disease Risk Prediction Models

Кібернетика та комп'ютерні технології
Introduction. Non-communicable diseases, especially cardiovascular pathologies, remain the leading cause of mortality worldwide, creating a significant burden on society, the economy, and healthcare systems.
Margaryta Prazdnikova
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Data analysis model to categorize the level of cardiovascular risk in the Department of Atlantico-Colombia

TESEA, Transactions on Energy Systems and Engineering Applications
This article proposes a model based on data analysis to categorize the level of cardiovascular risk in department of Atlantico-Colombia. In the process, the fundamental concepts on which this research proposal was based were identified.
Paul Sanmartin, Luis Consuegra, Diana Heredia, Moinca Huerta   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source