Results 161 to 170 of about 360,574 (311)

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Research on content adjustment and clinical application of "guidelines of venous blood specimen collection"

Huli yanjiu, 2022
WANG Shufen, ZHANG Junmei, JIANG Qiuhuan, ZHANG Hongmei, SHI Zhiyi, MIAO Xiaohui, KONG Sha   +6 more
doaj  

FIND integrated biobanks: A network model for efficiency and preparedness based on equitable partnership contracts. [PDF]

J Clin Transl Sci
Fransman W, El Idrissi I, Biga R, Emperador D, Adedosu N, Caceres T, Etafo J, Ishara-Nshombo E, Kavunga-Membo H, Mukadi-Bamuleka D, Muthoni M, Noroc E, Ntusi N, Ogbaini-Emovon E, Romancenco E, Taylor-Meyer N, Zamudio Fuertes C, Saxena A, Allen D, Betsou F, Alirol E.   +20 more
europepmc   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

The Complete Genome Sequence of the Black Mussurana snake (<i>Clelia clelia</i>). [PDF]

Biodivers Genomes
Angarita-Sierra T, Pulido-Santacruz P, Pirro S, Sánchez-Pacheco SJ.   +3 more
europepmc   +1 more source

Peekskill City School District and Peekskill Association of Educational Secretaries, Peekskill Faculty Association, NYSUT (2004) [PDF]

, 2004

core   +1 more source

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Observation on status quo of nurses’ blood specimen collection operation

Huli yanjiu, 2018
CAO Qiujun, WU Yan
doaj  

Optimal Specimens and Lesions for Mpox Diagnosis Using Real-Time PCR, South Korea. [PDF]

Emerg Infect Dis
Kim DM, Muhammad M, Kim JW, Kim CM, Seo JW, Kim DY, Yun NR, Lee B, Lee M, Lee JH, Choi MM, Chung YS.   +11 more
europepmc   +1 more source