Results 31 to 40 of about 21,882 (168)

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

Advanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao, Xu‐Ying Pei, Yuan‐Yuan Zhang, Juan Xie, Jing‐Wei Tu, Zhuo‐Jun Liu, Yi‐Yang Ding, Chen‐Hua Yan, Yu‐Hong Chen, Yu Wang, Lan‐Ping Xu, Xiao‐Hui Zhang, Xiao‐Jun Huang, Xiang‐Yu Zhao   +13 more
wiley   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Risk factors for allogeneic red blood cell transfusion in adult spinal deformity surgery [PDF]

Asian Spine Journal
Study Design Retrospective study. Purpose To investigate the risk factors for allogeneic red blood cell (RBC) transfusion in adult spinal deformity (ASD) surgery.
Yasushi Iijima, Toshiaki Kotani, Tsuyoshi Sakuma, Tsutomu Akazawa, Shunji Kishida, Keisuke Ueno, Shohei Ise, Yosuke Ogata, Masaya Mizutani, Yasuhiro Shiga, Shohei Minami, Seiji Ohtori   +11 more
doaj   +1 more source

Hemolysis Detected Following the Preparation and Collection of Blood in a Porcine Model Using a Syringe‐Based Aspiration Thrombectomy System for Autotransfusion

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Autologous transfusion of filtered, unwashed blood is a technique to mitigate the effects of blood loss during mechanical thrombectomy, but the degree of hemolysis resulting from this approach and guidance for blood return in this setting is not well understood.
Suhail Dohad, Mohammed M. Hoque, Jonathan H. Waters, Marc Salhanick   +3 more
wiley   +1 more source

A review of the application of autologous blood transfusion

Brazilian Journal of Medical and Biological Research, 2016
Autologous blood transfusion (ABT) has been gradually attracting more attention due to the increasingly prominent problem of blood transfusion safety and blood shortage in recent years.
J. Zhou
doaj   +1 more source

Intraoperative blood collection without fluid replacement for cardiac surgery – A retrospective analysis

Annals of Cardiac Anaesthesia, 2022
Background: Transfusion rates in cardiac surgery are high. Aim: To determine if intraoperative autologous blood removal without volume replacement is associated with fewer homologous blood transfusions without increasing acute kidney injury.
Jennifer L Vance, Lisa Irwin, Elizabeth S Jewell, Milo Engoren   +3 more
doaj   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Preliminary exploration on operation process for autologous ozonized blood transfusion

Zhongguo shuxue zazhi, 2023
Autologous ozonized blood transfusion(AOBT) is a therapy of re-transfusion of 100-200 mL of autologous blood after shaking and agitation with appropriate amount of oxygen-ozone in vitro.
Jianjun WU, Yan BAI, Yanli BAI, Zhanshan ZHA, Jing CHEN, Yahan FAN, Jiwu GONG, Shouyong HUN, Hongbing LI, Zhongjun LI, Jiajin LIN, Chunxia LIU, Fenghua LIU, Jiubo LIU, Jingling LUO, Xianjun MA, Deying MENG, Shijie MU, Mei QIN, Hui WANG, Haiyan WANG, Qiushi WANG, Quanli WANG, Xiaoning WANG, Yongjun WANG, Changsong WU, Lin WU, Jue XIE, Pu XU, Liying XU, Mingchia YANG, Yongtao YANG, Yang YU, Zebo YU, Juan ZHANG, Xiaoyu ZHOU, Xuelian ZHOU, Shuming ZHAO   +37 more
doaj   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source