Results 101 to 110 of about 245,440 (308)

Chronic Kidney Disease Increases Cerebral Microbleeds in Mouse and Man. [PDF]

, 2020
Brain microbleeds are increased in chronic kidney disease (CKD) and their presence increases risk of cognitive decline and stroke. We examined the interaction between CKD and brain microhemorrhages (the neuropathological substrate of microbleeds) in ...
Bangash, Maria, Cribbs, David H, Fisher, Mark, Floriolli, David, Lau, Wei Ling, Lertpanit, Long, Naqvi, Sameen, Nunes, Ane CF, Paganini-Hill, Annlia, Savoj, Javad, Shah, Krunal, Vasilevko, Vitaly, Vaziri, Nosratola D, Yao, Zhihui   +13 more
core  

Predicting early risk of chronic kidney disease in cats using routine clinical laboratory tests and machine learning. [PDF]

, 2019
BackgroundAdvanced machine learning methods combined with large sets of health screening data provide opportunities for diagnostic value in human and veterinary medicine.Hypothesis/objectivesTo derive a model to predict the risk of cats developing ...
Bradley, Richard, De Meyer, Geert, Elliott, Jonathan, Kennedy, James, Kim, Minseung, Kokkinos, Yiannis, Panagiotakos, Theodoros, Tagkopoulos, Ilias, Watson, Phillip   +8 more
core   +2 more sources

Neutrophil‐Driven Cascade‐Targeted Nanocarriers Restore Mitochondrial Homeostasis to Ameliorate Renal Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A neutrophil‐mediated dual‐targeting liposome (NKN‐LNP) is developed to treat renal ischemia–reperfusion injury. The system enables spatiotemporally controlled delivery of NMN to injured tubules via MMP‐2/9 activation and KIM1 recognition, restoring mitochondrial function through NAD+‐SIRT3 signaling and preventing the transition from acute kidney ...
Hangbin Ma, Yang Li, Shen Lin, Feifan Chu, Gaozhan Ren, Yinhui Mao, Mingzhi Wu, Yuning Ma, Qiwei Ji, Zujie Chen, Jinzhong Ji, Mingxin Sun, Yongpeng Xu, Xiaoli Sun, Longguang Tang, Hao Zhou   +15 more
wiley   +1 more source

Impact of urea as a protein substitute in growing camel rations on performance, nitrogen balance, blood metabolites, immune status, and rumen fermentation

Open Veterinary Journal
Background: Urea, a non-protein nitrogen, is a widely utilized, affordable, and readily available protein supplement. Aim: This work aimed to investigate the effect of urea as a protein substitute in growing camel ration on performance, digestion ...
Heba A. Nasr, Ghada S. E. Abdel-Raheem, Abdelbaset Ahmed, Walaa M. S. Gomaa   +3 more
doaj   +1 more source

Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis

Advanced Science, EarlyView.
Considering the great challenge in Glioblastoma multiforme (GBM) treatment, the authors designed and synthesized a multifunctional nanoplatform that effectively induced ferroptosis by synergetically inhibiting intrinsic intrisinc anti‐ferroptosis proteins, GPX4 & DHODH, and realized excellent in vitro and in vivo anti‐GBM effect.
Guodong Ren, Xuewei Wang, Panpan Li, Hao Wu, Zhifei Bi, Qi Gao, Bolong Ma, Zixuan Tian, Jianfei Liu, Fuqiang Feng, Wen Liu, Lin Li, Chengwu Zhang   +12 more
wiley   +1 more source

Novel Vascular‐Adaptive Liquid Metal Microspheres Enable Visualized Arterial Embolization Therapy

Advanced Science, EarlyView.
We present drug‐loaded liquid metal microspheres (X‐MEN) as a novel agent for image‐guided arterial embolization. With inherent radiopacity and superior deformability, X‐MEN enables real‐time monitoring and conforms tightly to irregular vessels. This approach ensures precise, long‐lasting embolization without recanalization, addressing critical ...
Chenyu Shen, Junge Chen, Gang Zhang, Zhusheng Liu, Yichen Wan, Lei Lei, Weiyan Ren, Yanyu Zhao, Bozhang Xia, Zhiqiang Yi, Jinjin Wang, Jingwang Gao, Gen Mu, Xing‐Jie Liang, Zhijun Wang   +14 more
wiley   +1 more source

Ruminal characteristics, blood pH, blood urea nitrogen and nitrogen balance in Nili-Ravi buffalo (bubalus bubalis) bulls fed diets containing various level of ruminally degradable protein

Italian Journal of Animal Science, 2010
Ruminal degradable protein (RDP) is considered essential for ruminal microbial growth. This not only improves the ruminal fermentation but it also ensures an adequate supply of microbial protein to the host animal.
M.A. Shahzad, A. Javaid, M. Nisa, M. Sarwar   +3 more
doaj   +1 more source

Nitrogen efficiency of dairy cattle : from protein evaluation to ammonia emission [PDF]

, 2011
Diet optimization contributes considerably to increased nitrogen efficiency of dairy cattle, resulting in reduced nitrogen losses. This thesis focuses on three themes: the potential advances in protein evaluation systems for ruminants, the relationship ...
Duinkerken, G., van
core  

Orthotopic liver transplantation for urea cycle enzyme deficiency [PDF]

, 1992
Hyperammonemia, abnormalities in plasma amino acids and abnormalities of standard liver functions were corrected by orthotopic liver transplantation in a 14‐day‐old boy with carbamyl phosphate synthetase‐I deficiency and in a 35‐yr‐old man with ...
Bachmann, Broelsch, Brusilow, Brusiow, Featherston, Green, Largilliere, Moore, Nuzum, Roth, Saheki, Starzl, Starzl, Voorhies, Windmueller, Wood, Wood   +16 more
core   +1 more source

NSUN5 Attenuates Renal Injury and Ferroptosis in Hyperuricaemic Nephropathy Through YBX2‐Dependent Stabilisation of SCD1 m5C Methylation

Advanced Science, EarlyView.
NSUN5 is downregulated in hyperuricaemic nephropathy. Overexpression of NSUN5 enhances the stability of SCD1 mRNA through the m5C reader YBX2, ultimately inhibiting ferroptosis in renal tubular epithelial cells. Additionally, this axis suppresses the NF‐κB signaling pathway to alleviate inflammation and upregulates ABCG2 to promote uric acid excretion,
Xiu‐xiu Song, Xiao‐guo Suo, Yue Yu, Kuo Zhang, Chen‐ao Li, Jie Wang, Hui‐xia Xu, Si‐yu Niu, Dong‐xue Lv, Zi‐hao He, Feng‐he Li, Xiao‐ming Meng, Juan Jin   +12 more
wiley   +1 more source