Results 171 to 180 of about 5,657,221 (393)

SIRT3 and RORα are two prospective targets against mitophagy during simulated ischemia/reperfusion injury in H9c2 cells

Heliyon
Autophagy during myocardial ischemia/reperfusion (MI/R) exacerbates cardiomyocyte injury. Melatonin (Mel) alleviates myocardial damage by regulating mitochondrial function and mitophagy, but the role of mitophagy in melatonin-induced cardioprotection ...
Jinjing Wu, Yanli Yang, Duomao Lin, Zhaoqi Wang, Jun Ma   +4 more
doaj   +1 more source

Rebuilding blood vessels [PDF]

Nature Biotechnology, 1999
openaire   +2 more sources

Peristaltic Pumping of Blood Through Small Vessels of Varying Cross-section

, 2012
The paper is devoted to a study of the peristaltic motion of blood in the micro-circulatory system. The vessel is considered to be of varying cross-section. The progressive peristaltic waves are taken to be of sinusoidal nature. Blood is considered to be
Anand, Barbee, Bhargava, Blair, Bohme, Brassur, Bugliarello, Chakraborty, Charm, Charm, Chien, Fung, Fung, Gupta, Guyton, Hayat, Higdon, Huang, J. C. Misra, Jaffrin, Jimenez-Lozano, Jimenez-Lozano, Kwack, Lardner, Lee, Li, Maiti, Maiti, Malek, Masud, Merrill, Mishra, Misra, Misra, Misra, Misra, Misra, Misra, Misra, Misra, Misra, Misra, Misra, Misra, Pozrikidis, Provost, Rand, S. Maiti, Selvarajan, Shapiro, Srivastava, Srivastava, Srivastava, Takabatake, Usha, Usha, Wang, White, Wiederhielm, Wiedman, Xue, Yaniv   +61 more
core   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

A Process-Oriented Architecture for Complex System Modelling [PDF]

, 2007
A fine-grained massively-parallel process-oriented model of platelets (potentially artificial) within a blood vessel is presented. This is a CSP inspired design, expressed and implemented using the occam-pi language. It is part of the TUNA pilot study on
Ritson, Carl G., Welch, Peter H.
core  

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Human blood vessel organoids as a model of diabetic vasculopathy

Nature, 2019
Reiner A. Wimmer, Alexandra Leopoldi, Martin Aichinger, N. Wick, B. Hantusch, M. Novatchkova, Jasmin Taubenschmid, M. Hämmerle, Christopher Esk, J. Bagley, Dominik Lindenhofer, Guibin Chen, M. Boehm, Chukwuma A. Agu, Fengtang Yang, B. Fu, J. Zuber, Juergen A. Knoblich, D. Kerjaschki, J. Penninger   +19 more
semanticscholar   +1 more source

Insight into the Internal Structure of Biogenic, Synthetic and Geological Apatite by Electron Microscopy and X‐Ray Scattering

Advanced Functional Materials, EarlyView.
Apatite occurs in many forms in nature, e.g. in teeth and geological minerals. Internally, biological apatite contains nanocrystals that are also found in synthetically prepared calcium phosphate nanoparticles which are used in biomedicine, e.g. for gene and drug delivery and for bone regeneration. Abstract Calcium phosphate is the inorganic component (
Kathrin Kostka, Oleg Prymak, Kateryna Loza, Matthias Epple   +3 more
wiley   +1 more source

Bioinspired Bromination Enables Extensible, Strain‐Stiffening Resilin Peptide Scaffolds with Tunable Degradation

Advanced Functional Materials, EarlyView.
Bioinspired bromination of a resilin‐derived peptide enables the fabrication of electrospun nanofibrous scaffolds that uniquely combine strain‐stiffening elasticity, proteolytic stability, and antioxidant functionality. These brominated peptide–gelatin hybrids mimic the extensibility of natural elastomers, demonstrating tunable mechanical resilience ...
Elisa Marelli, Lorenzo Sori, Chiara Russo, Claudia Pigliacelli, Lorenza Draghi, Monica Soncini, Pierangelo Metrangolo   +6 more
wiley   +1 more source

The association of triglyceride–glucose index with major adverse cardiovascular and cerebrovascular events after acute myocardial infarction: a meta-analysis of cohort studies

Nutrition & Diabetes
Background Insulin resistance (IR) is indicated to be linked with adverse outcomes of acute myocardial infarction (AMI), for its pro-inflammatory and pro-thromboplastic function. The triglyceride-glucose (TyG) index is a newly developed substitute marker
Huiruo Liu, Liangshan Wang, Hong Wang, Xing Hao, Zhongtao Du, Chenglong Li, Xiaotong Hou   +6 more
doaj   +1 more source