Results 41 to 50 of about 1,617,809 (256)

EFFECT OF MODIFIED ULTRAFILTRATION ON HEMODYNAMICS IN PEDIATRIC CARDIAC SURGERY AT ARMED FORCES INSTITUTE OF CARDIOLOGY/ NATIONAL INSTITUTE OF HEART DISEASES (AFIC/NIHD)

Pakistan Armed Forces Medical Journal, 2020
Objective: To observe the effect of modified ultrafiltration on hemodynamics of pediatric patients. Study Design: A descriptive cross-sectional study. Place and Duration of Study: Pediatric Cardiac Surgery department, AFIC/NIHD Rawalpindi, from Jun
Muneeb Ur Rehman, Tariq Rao, Naila Niaz, Shahid Nafees, Naseem Azad, Muhammad Shoaib Umar   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Measurement of blood flow in the human Achilles tendon in vivo

Journal of Physical Fitness and Sports Medicine, 2017
The purpose of this study was to apply a high-power laser blood flowmeter and laser oxygenation monitor to investigate 1) changes during a single isometric contraction and 2) changes after repeated contractions in blood flow (BF), blood volume (THb), and
Keitaro Kubo, Tomonobu Ishigaki, Toshihiro Ikebukuro   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hematological Adaptations to Prolonged Heat Acclimation in Endurance-Trained Males

Frontiers in Physiology, 2019
Heat acclimation is associated with plasma volume (PV) expansion that occurs within the first week of exposure. However, prolonged effects on hemoglobin mass (Hbmass) are unclear as intervention periods in previous studies have not allowed sufficient ...
Laura Oberholzer, Christoph Siebenmann, Christoph Siebenmann, C. Jacob Mikkelsen, Nicklas Junge, Jacob F. Piil, Nathan B. Morris, Jens P. Goetze, Jens P. Goetze, Anne-Kristine Meinild Lundby, Lars Nybo, Carsten Lundby, Carsten Lundby   +12 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Pilot study of combined FDG‐PET and dynamic contrast‐enhanced CT of locally advanced cervical carcinoma before and during concurrent chemoradiotherapy suggests association between changes in tumor blood volume and treatment response

Cancer Medicine, 2018
Modern PET/CT radiotherapy simulators offer FDG‐PET and dynamic contrast‐enhanced (DCE) CT imaging for combined volumetric assessment of tumor metabolism and perfusion. However, the clinical utility of such assessment has not been clearly defined.
Thomas I. Banks, Rie vonEyben, Dimitre Hristov, Elizabeth A. Kidd   +3 more
doaj   +1 more source

Influence of Endurance Training During Childhood on Total Hemoglobin Mass

Frontiers in Physiology, 2018
Elite endurance athletes are characterized by markedly increased hemoglobin mass (Hbmass). It has been hypothesized that this adaptation may occur as a response to training at a very young age.
Nicole Prommer, Nadine Wachsmuth, Ina Thieme, Christian Wachsmuth, Erica M. Mancera-Soto, Andreas Hohmann, Walter F. J. Schmidt   +6 more
doaj   +1 more source