Results 111 to 120 of about 332,554 (303)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Hyperglycemia Is Associated With Computed Tomography Perfusion Core Volume Underestimation in Patients With Acute Ischemic Stroke With Large‐Vessel Occlusion

Stroke: Vascular and Interventional Neurology
Background Computed tomography perfusion (CTP) predictions of infarct core play an important role in the determination of treatment eligibility in large‐vessel occlusion acute ischemic stroke. Prior studies have demonstrated that blood glucose can affect
Arash Niktabe, Juan Carlos Martinez‐Gutierrez, Sergio Salazar‐Marioni, Rania Abdelkhaleq, Juan Carlos Rodriguez Quintero, Jerome A. Jeevarajan, Muhammad Bilal Tariq, Ananya S. Iyyangar, Hussain M. Azeem, Anjan Nagesh Ballekere, Ngoc Mai Le, Louise D. McCullough, Sunil A. Sheth, Youngran Kim   +13 more
doaj   +1 more source

Haematological and Genotoxic effects of cadmium chloride on Mesopotamichthys sharpeyi

مجلة بغداد للعلوم, 2016
The present study investigated Haematological changes in Mesopotamichthys sharpeyi, as well as determination genotoxic effects of cadmium chloride on bunni fish by using 120 fingerlings, fish were distributed randomly into four treatments in addition to ...
Baghdad Science Journal
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Blood volume changes after radiotherapy of the CNS [PDF]

, 1996
Background: The pathogenesis of late delayed radiation damage in normal brain tissue is most likely due to damage to the vascular endothelium. The mitotic activity of gliomas was shown to correlate with the tumor induced angiogenesis.
Wenz F., Knopp M. V., Fuss M., Engenhart R., Wannenmacher M., Scholdei R., Lohr F., Rempp K., Brix G., Essig M.   +9 more
core  

Neuromuscular Blockade with Rocuronium Bromide Increases the Tolerance of Acute Normovolemic Anemia in Anesthetized Pigs [PDF]

, 2012
Background: The patient's individual anemia tolerance is pivotal when blood transfusions become necessary, but are not feasible for some reason. To date, the effects of neuromuscular blockade (NMB) on anemia tolerance have not been investigated. Methods:
Horn, O., Stein, P., Kertscho, H., Lossen, M., Zwissler, Bernhard, Pape, A., Kutschker, S., Habler, O.   +7 more
core   +1 more source

INFLUENCE OF ARTIFICIAL HUMAN ADAPTATION TO INTERMITTENT NORMOBARIC ANOXIA ON THE OPTIONS OF ERYTHROCYTES OF CIRCULATING BLOOD

Медицинский вестник Юга России, 2014
Purpose: to estimate changes and dynamics of the options of circulating blood erythrocytes in artificial human adaptation to intermittent normobaric hypoxia.Materials and methods: Sixteen healthy male volunteers aged 20-24 years were underwent to course ...
T. Y. Bykovskaya, D. V. Shatov, A. O. Ivanov, V. F. Belyaev, M. V. Mazur   +4 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Bioanalysis of Small Molecule Pharmaceuticals: Simultaneous Determination in Biological Fluid Samples from Multiple Species by the Management of Matrix Effects [PDF]

A strategy is described for method evaluation to manage the influence of endogenous compounds to induce bias in pharmaceutical quantification from blood samples of different animal species resulting from ionisation matrix effects. The approach introduces
Gray, Nicholas
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source