Results 51 to 60 of about 331,507 (304)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Blood Volume [PDF]

, 1981
the principle underlying the methodology of blood volume determination involves the determination of degree of dilution of an injected dye by comparing the concentration of the injected dye and the concentration of the dye in the blood after a ...
Ravindranath, M H, Mullainadhan, P
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Mechanisms underlying the volume regulation of interstitial fluid by capillaries: a simulation study

Integrative Medicine Research, 2016
Background: Control of the extracellular fluid volume is one of the most indispensable issues for homeostasis of the internal milieu. However, complex interdependence of the pressures involved in determination of fluid exchange makes it difficult to ...
Yukiko Himeno, Masayuki Ikebuchi, Akitoshi Maeda, Akinori Noma, Akira Amano   +4 more
doaj   +1 more source

Determination of blood volume by pulse CO-oximetry [PDF]

Physiological Measurement, 2011
The objective of this study was to determine whether changes in carboxyhaemoglobin (COHb) saturation following carbon monoxide (CO) rebreathing can be accurately detected by pulse CO-oximetry in order to determine blood volume. Noninvasive measurements of carboxyhaemoglobin saturation (SpCO) were continuously monitored by pulse CO-oximetry before ...
S, Lalande, J W, Kelsey, M J, Joyner, B D, Johnson   +3 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Fluorescence Exclusion: A Simple Method to Assess Projected Surface, Volume and Morphology of Red Blood Cells Stored in Blood Bank

Frontiers in Medicine, 2018
Red blood cells (RBC) ability to circulate is closely related to their surface area-to-volume ratio. A decrease in this ratio induces a decrease in RBC deformability that can lead to their retention and elimination in the spleen.
Camille Roussel, Camille Roussel, Camille Roussel, Camille Roussel, Camille Roussel, Sylvain Monnier, Michael Dussiot, Michael Dussiot, Elisabeth Farcy, Olivier Hermine, Olivier Hermine, Olivier Hermine, Olivier Hermine, Caroline Le Van Kim, Caroline Le Van Kim, Caroline Le Van Kim, Yves Colin, Yves Colin, Yves Colin, Matthieu Piel, Matthieu Piel, Pascal Amireault, Pascal Amireault, Pascal Amireault, Pascal Amireault, Pierre A. Buffet, Pierre A. Buffet, Pierre A. Buffet, Pierre A. Buffet, Pierre A. Buffet   +29 more
doaj   +1 more source

Insights into diastolic function analyses using cardiac magnetic resonance imaging: impact of trabeculae and papillary muscles

Insights into Imaging, 2021
Background This cardiovascular magnetic resonance (CMR) study investigates the impact of trabeculae and papillary muscles (TPM) on diastolic function parameters by differentiation of the time-volume curve.
Bjoern P. Schoennagel, Kai Müllerleile, Enver Tahir, Jitka Starekova, Regine Grosse, Jin Yamamura, Peter Bannas, Gerhard Adam, Roland Fischer   +8 more
doaj   +1 more source

Theoretical investigation of measuring cerebral blood flow in the adult human head using bolus indocyanine green injection and near-infrared spectroscopy [PDF]

, 2007
To investigate the accuracy of measuring cerebral blood flow (CBF) using a bolus injection of indocyanine green (ICG) detected by near infrared spectroscopy in adult human heads, simulations were performed using a two layered model, representing the ...
Tachtsidis, I, Tachtsidis, I., Delpy, D., Tisdall, M, Leung, T., Smith, M., Elwell, CE, Elwell, C., Delpy, DT, Tisdall, M., Leung, TS, Smith, M   +11 more
core  

Survival with Treated and Well-Controlled Blood Pressure: Findings from a Prospective Cohort Study. [PDF]

, 2011
AIM: To compare survival and incident cardiovascular disease between normotensive, untreated hypertensive, treated and poorly-controlled hypertensive and treated and well-controlled hypertensive adults.
Peter Whincup, Lawlor Debbie A., Ebrahim, S, Lawlor, Debbie A, Kim Lois, Morris, Richard, Amuzu Antoinette, Shah Ebrahim, Kim, Lois, Ebrahim, Shah, Debbie A. Lawlor, Whincup, Peter, Lois Kim, Morris Richard, Whincup, P, Antoinette Amuzu, Amuzu, A, Amuzu, Antoinette, Whincup Peter, Morris, R, Richard Morris, Lawlor, DA, Debbie A Lawlor, Kim, L, Ebrahim Shah   +24 more
core   +1 more source