Results 91 to 100 of about 211,876 (308)

Effect of daptomycin and vancomycin on Staphylococcus epidermidis biofilms: An in vitro assessment using fluorescence in situ hybridization [PDF]

, 2019
Colonization of in-dwelling catheters by microbial biofilms is a major concern in patient health eventually leading to catheter-related blood stream infections.
Affeld, Klaus, Gabel, Grischa, Gebhardt, M., Goubergrits, Leonid, Kertzscher, Ulrich, Kikhney, Judith, Kursawe, Laura, Moter, Annette, Petrich, A., Schmidt, Julia, Sutrave, Smita, Wiessner, Alexandra   +11 more
core   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Small Colony Variants of Staphylococcus aureus and Pacemaker-related Infection

Emerging Infectious Diseases, 2003
We describe the first known case of a device-related bloodstream infection caused by Staphylococcus aureus small colony variants. Recurrent pacemaker-related bloodstream infection within a 7-month period illustrates the poor clinical and microbiologic ...
Harald Seifert, Hilmar Wisplinghoff, Petra Schnabel, Christof von Eiff   +3 more
doaj   +1 more source

Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice

Advanced Science, EarlyView.
ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao, Xiaofan Jiang, Md Moniruzzaman, Alexandra Mueller, Taskeen Iqbal Janjua, Nisha Tyagi, Zhi Qu, Kuan Yau Wong, Yuran Feng, Aayushi Ghodasara, Ekaterina Strounina, Benjamin P. Ross, Tushar Kumeria, Sumaira Z. Hasnain, Amirali Popat   +14 more
wiley   +1 more source

Staphylococcus lugdunensis Pacemaker-related Infection

Emerging Infectious Diseases, 2005
We report the first known case of a device-related bloodstream infection involving Staphylococcus lugdunensis small-colony variants. Recurrent pacemaker-related bloodstream infection within a period of 10 months illustrates the poor clinical and ...
Harald Seifert, Dirk Oltmanns, Karsten Becker, Hilmar Wisplinghoff, Christof von Eiff   +4 more
doaj   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

Computer Algorithms To Detect Bloodstream Infections

Emerging Infectious Diseases, 2004
We compared manual and computer-assisted bloodstream infection surveillance for adult inpatients at two hospitals. We identified hospital-acquired, primary, central-venous catheter (CVC)-associated bloodstream infections by using five methods ...
William E. Trick, Brandon M. Zagorski, Jerome I. Tokars, Michael O. Vernon, Sharon F. Welbel, Mary F. Wisniewski, Chesley Richards, Robert A. Weinstein   +7 more
doaj   +1 more source

Human infectivity trait in Trypanosoma brucei: stability, heritability and relationship to sra expression [PDF]

, 2004
Some Trypanosoma brucei lines infect humans whereas others do not because the parasites are lysed by human serum. We have developed a robust, quantitative in vitro assay based on differential uptake of fluorescent dyes by live and dead trypanosomes to ...
Bisoni, L., Lindergard, L.A.G., MacLeod, A., McLellan, S., Tait, A., Turner, C.M.R.   +5 more
core   +1 more source

Enzymatic DNA Reaction Networks for Orchestrating Stimuli‐Dependent Temporal Molecular Pulse

Advanced Science, EarlyView.
We present an enzymatic DNA reaction network (EDRN) that encodes nucleic‐acid targets in time, converting inputs into a universal strand and then into programmable transient fluorescence pulses. With time‐color multiplexing, EDRN enables single‐tube high‐plex nucleic acid detection and shows strong agreement with clinical sequencing across 32 specimens.
Jiayu Yang, Yali Chang, Zibin Chu, Linghao Zhang, Tengfang Zhang, Dai Erhei, Xin Su, Zhe Yin   +7 more
wiley   +1 more source

Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics

Advanced Science, EarlyView.
 . ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao, Bingyao Bai, Xingqian Ye, Yiliang Lin   +3 more
wiley   +1 more source