Results 31 to 40 of about 956,209 (253)

A multicenter evaluation of viral bloodstream detections in children presenting to the Emergency Department with suspected systemic infection

BMC Pediatrics, 2021
Background Fever is a common symptom in children presenting to the Emergency Department (ED). We aimed to describe the epidemiology of systemic viral infections and their predictive values for excluding serious bacterial infections (SBIs), including ...
Christina A. Rostad, Neena Kanwar, Jumi Yi, Claudia R. Morris, Jennifer Dien Bard, Amy Leber, James Dunn, Kimberle C. Chapin, Anne J. Blaschke, Judy A. Daly, Leslie A. Hueschen, Matthew Jones, Elizabeth Ott, Jeffrey Bastar, Kevin M. Bourzac, Rangaraj Selvarangan   +15 more
doaj   +1 more source

Central Line-Associated Bloodstream Infection Prevention in the Long-Term Acute Care Setting [PDF]

, 2012
Sustained reduction of central line-associated bloodstream infections remains elusive in many institutions, including the long-term acute care hospital (LTACH), despite a focus on improving patient outcomes.
Dougherty, Mary Lisbeth, MSN RN AOCNA
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Reducing the rate of central line-associated bloodstream infections; a quality improvement project

BMC Infectious Diseases, 2023
Background The burden of central line-associated bloodstream infections is significant and has negative implications for healthcare, increasing morbidity and mortality risks, increasing inpatient hospital stays, and increasing the cost of hospitalization.
David Odada, Hellen Munyi, Japhet Gatuiku, Ruth Thuku, Jared Nyandigisi, Anne Wangui, Emilie Ashihundu, Beatrice Nyakiringa, Jemimah Kimeu, Martin Musumbi, Rodney D. Adam   +10 more
doaj   +1 more source

Use of chlorhexidine for the prophylaxis of nosocomial infections in ICU [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2020
This review summarizes published data on the use of chlorhexidine for the prevention of nosocomial infections in the intensive care units (ICU). The use of a 0.5–2.0% alcohol solution of chlorhexidine is strongly recommended for the surgical site ...
Bagin V.A., Rudnov V.A., Astafieva M.N.
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei [PDF]

, 2013
African trypanosomes are sustained in the bloodstream of their mammalian hosts by their extreme capacity for antigenic variation. However, for life cycle progression, trypanosomes also must generate transmission stages called stumpy forms that are pre ...
Szoor, Balazs; id_orcid, Matthews, KR, Binny M. Mony, Keith Roland Matthews, Paula MacGregor, Paula eMacGregor, Mony, BM, Mony, B, Balazs eSzoor, Macgregor, Paula, Matthews, Keith R; id_orcid, MacGregor, P, Matthews, K, Mony, Binny M, Balazs Szoor, Rojas, Federico, Rico, Eva, Keith R. Matthews, Eva eRico, Rojas, F, Eva Rico, Federico Rojas, Szoor, B, Federico eRojas, Binny M Mony, Rico, E   +25 more
core   +1 more source

Health itinerary-related survival of children under-five with severe malaria or bloodstream infection, DR Congo.

PLoS Neglected Tropical Diseases, 2023
BackgroundPrompt appropriate treatment reduces mortality of severe febrile illness in sub-Saharan Africa. We studied the health itinerary of children under-five admitted to the hospital with severe febrile illness in a setting endemic for Plasmodium ...
Bieke Tack, Daniel Vita, José Nketo, Naomie Wasolua, Nathalie Ndengila, Natacha Herssens, Emmanuel Ntangu, Grace Kasidiko, Gaëlle Nkoji-Tunda, Marie-France Phoba, Justin Im, Hyon Jin Jeon, Florian Marks, Jaan Toelen, Octavie Lunguya, Jan Jacobs   +15 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Healthcare-associated infection in the Grey’s Hospital paediatric intensive care unit: does an Infection Control Programme work?

Southern African Journal of Infectious Diseases, 2018
Background: Healthcare-associated infections are an important cause of morbidity and mortality globally. Grey’s Hospital introduced an Infection Control Programme in August 2016, which included Best Care Always bundles for reducing the occurrence of ...
Anne L. Armour, Mark E. Patrick, Zelda Reddy, Wilbert Sibanda, Logandran Naidoo, Kevin B. Spicer   +5 more
doaj   +1 more source