Results 161 to 170 of about 548,148 (264)

Antitumoral Efficacy of AuNRs‐Laden ECFCs In Vitro and In Vivo: Decoding the Heat and Rays Combo Treatment in Breast Cancer and Melanoma Cells

Advanced Healthcare Materials, EarlyView.
Endothelial Colony Forming Cells (ECFCs) acted as cellular cyborgs, stealthily transporting gold nanorods (AuNRs) into tumors to enable targeted near‐infrared (NIR) hyperthermia combined with radiotherapy. This approach triggers ferroptosis in melanoma and inhibits autophagy in breast cancer, revealing a tumor‐specific response to nanomaterial‐assisted
Cecilia Anceschi, Francesca Scavone, Paolo Armanetti, Luca Menichetti, Claudia Catarinicchia, Claudia Borri, Fulvio Ratto, Filippo Micheletti, Noemi Formica, Jessica Ruzzolini, Elena Frediani, Anastasia Chillà, Francesca Margheri, Mirko Severi, Rita Traversi, Patrizia Nardini, Daniele Guasti, Mario Del Rosso, Tommaso Del Rosso, Lisa Giovanelli, Cinzia Talamonti, Monica Mangoni, Isacco Desideri, Silvia Burchielli, Fabiola Pajar, Gabriella Fibbi, Anna Laurenzana   +26 more
wiley   +1 more source

A 96-Well Polyacrylamide Gel for Electrophoresis and Western Blotting

ACS Omega
Marc R. Birtwistle, Jonah R. Huggins, Cameron O. Zadeh, Deepraj Sarmah, Sujata Srikanth, B. Kelly Jones, Lauren N. Cascio, Delphine Dean   +7 more
doaj   +1 more source

METTL9 mediated N1-Histidine methylation of SLC39A7 confers ferroptosis resistance and inhibits adipogenic differentiation in mesenchymal stem cells. [PDF]

Mol Med
Jin J, Li Q, Zhang Y, Ji P, Wang X, Zhang Y, Yuan Z, Jiang J, Tian G, Cai M, Feng P, Wu Y, Wang P, Liu W.   +13 more
europepmc   +1 more source

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source

OGA promotes human dental pulp stem cell senescence and inhibits mitophagy by inhibition of O-GlcNAcylation of KLF2. [PDF]

BMC Oral Health
Ding Y, Ran Y.
europepmc   +1 more source

Biomimetic Dynamics of Nanoscale Groove and Ridge Topography for Stem Cell Regulation

Advanced Materials, EarlyView.
Dynamic nanoscale groove‐ridge structures are engineered by flexibly conjugating RGD‐magnetic nanoparticles to nanogroove templates with variable groove widths at the molecular scale. Magnetic control enables cyclic switching between nanoscale groove and ridge states that modulates ligand accessibility of cellular integrins.
Hyunsik Hong, Dahee Kim, Hwapyung Jung, Seongyeol Kim, Sunhong Min, Chowon Kim, Kanghyeon Kim, Hyunji Rha, Heemin Kang   +8 more
wiley   +1 more source

Histone lactylation-induced premature senescence contributes to 1-nitropyrene-Induced chronic obstructive pulmonary disease. [PDF]

Redox Biol
Wang RR, Chen DL, Wei M, Li SR, Zhou P, Sun J, He QY, Yang J, Zhao H, Fu L.   +9 more
europepmc   +1 more source

Engineering CRISPR System‐Based Bacterial Outer Membrane Vesicle Potentiates T Cell Immunity for Enhanced Cancer Immunotherapy

Advanced Materials, EarlyView.
This study develops a multifunctional CRISPR‐dCas9‐based OMV platform termed OMV‐C9I12, which facilitates the coexpression of CXCL9 and IL‐12 within tumor cells. This platform enhances T cell recruitment and activation, synergizes with anti‐PD‐1/PD‐L1 immunotherapy, and amplifies antitumor T cell immunity.
Hongjin Wang, Hengji Zhan, Bolin Pan, Leli Zeng, Zehua Chen, Sen Liu, Qiang Zhang, Xuwei Hong, Junlin Lu, Xinrou Lin, Xiao Zhao, Jiajian Lai, Kaiwen Jie, Ye Li, Jianmei Zhong, Shengmeng Peng, Siting Chen, Changhao Chen, Wenlong Zhong, Shaoxu Wu, Yihang Pan, Tianxin Lin, Xu Chen   +22 more
wiley   +1 more source

Myometrial extracellular vesicles promoted endometrial mesenchymal stem/stromal cells to self-renewal via jag1-mediated notch signaling. [PDF]

Cell Commun Signal
Zhang S, Ng EHY, Yeung WSB, Chan RWS.
europepmc   +1 more source