Results 91 to 100 of about 7,172,762 (305)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Blue Stragglers in Low-Luminosity Star Clusters

, 2005
We examine the blue straggler populations of 13 low-luminosity (M_V_t >~ -6) globular clusters and 2 old open clusters. These clusters test blue straggler formation in environments intermediate between higher luminosity (and usually higher density ...
Eric L. Sandquist, Ferraro F. R.
core   +2 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Plant Growth Optimization Using Amber Light Supplemented with Different Blue Light Spectra

Horticulturae
Blue (400–500 nm) and red (600–700 nm) light regions have been investigated for their effects on photosynthesis and plant growth, yet evidence for specific blue light wavelengths in plant research is lacking.
Keli Trumpler, Bo-Sen Wu, Philip Wiredu Addo, Sarah MacPherson, Mark Lefsrud   +4 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Virtual water: A hidden natural resource in Serbia [PDF]

Ekonomija: teorija i praksa, 2015
Integrated water protection implies not only protection of water quality, but also protection of the quantity of useable water as one of the most important natural resources. This includes virtual water, which is water as an integral part of the product,
Galonja-Coghill Tamara, Nuhanović Miralem, Avdić Pašaga, Jahić Miralem, Stojnić Milica   +4 more
doaj  

The Spiritual Place of Blue Color in the Wall Painting Inscriptions of Islamic Architecture of Iran from the Second to the Eighth Century (AH) [PDF]

نگره
Color has been one of the most influential elements in expressing artistic features, ornaments and various elements since ancient times; although, less attention has been paid to the issue of why the choice of blue color is placed as the top color in ...
Mona Hassani Goharzad, Amirhossein Salehi   +1 more
doaj   +1 more source

Blue Marble Matches [PDF]

, 2009
This activity is designed to introduce students to geologic processes on Earth and how to identify geologic features in images. It also introduces students to how scientists use Earth to gain a better understanding of other planetary bodies in the solar ...

core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Ecosystem as curriculum: Fish farmer coastal field schools approach for resilient shrimp farming in sidoarjo, east jawa [PDF]

BIO Web of Conferences
Shrimp aquaculture in coastal East Java faces challenges related to fragile pond ecosystems, high input dependency, and increasing climate risks. To address these constraints, a participatory action research approach was implemented through the Fish ...
Fadilah Ratnawaty, Ali Syafriman, Arfandia Afan, Wahib Muhammad shodiqul   +3 more
doaj   +1 more source