Results 71 to 80 of about 2,770,785 (296)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Punctured Two-Dimensional Sheets for Harvesting Blue Energy [PDF]

open access: yesACS Nano, 2017
The challenges of global climate change and the world's growing demand for energy have brought the need for new renewable energy sources to the top of the international community's agenda. We have known for many centuries that energy is released upon mixing seawater and freshwater, yet it was just a few decades ago that it became clear how this energy ...
Aliprandi, Alessandro   +3 more
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Novel Thermal Desalination Brine Reject-Sewage Effluent Salinity Gradient for Power Generation and Dilution of Brine Reject

open access: yesEnergies, 2020
Salinity gradient resource presents an essential role for power generated in the process of pressure-retarded osmosis (PRO). Researchers proposed several designs for coupling the PRO process with the desalination plants, particularly reverse osmosis ...
Ali Altaee, Nahawand AlZainati
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Blue Energy Potential Analysis in the Mediterranean

open access: yesFrontiers in Energy Research, 2019
This paper describes the status of the potential of blue energy (BE) in the Mediterranean region, with focus on the region around Cyprus. Previous studies are reviewed, the main findings of the blue energy potential analysis performed in the frame of the
Georgios Nikolaidis   +5 more
doaj   +1 more source

Electrochemical Ion Pumping Device for Blue Energy Recovery: Mixing Entropy Battery

open access: yesApplied Sciences, 2020
In the process of finding new forms of energy extraction or recovery, the use of various natural systems as potential clean and renewable energy sources has been examined.
Felipe Galleguillos   +3 more
doaj   +1 more source

The cosmic gravitational wave background in a cyclic universe

open access: yes, 2003
Inflation predicts a primordial gravitational wave spectrum that is slightly ``red,'' i.e., nearly scale-invariant with slowly increasing power at longer wavelengths. In this paper, we compute both the amplitude and spectral form of the primordial tensor
A. Albrecht   +25 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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