Results 81 to 90 of about 833,779 (296)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Strategic Research Agenda towards innovation in Blue Energy [PDF]

, 2019
This document contains the Strategic Research Agenda to Innovation on Blue Energy developed in the framework of the PELAGOS project (D.4.2.1). Relying on both the current Research & Innvation guidelines and priorities established at European level for ...
Pisacane, G., Struglia, M.V., Sannino, Gianmaria, Carillo, A.   +3 more
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Faster Time Response by the Use of Wire Electrodes in Capacitive Salinity Gradient Energy Systems [PDF]

, 2012
Capacitive energy extraction based on Donnan potential (CDP) and capacitive energy extraction based on double layer expansion (CDLE) are novel electroctrochemical processes to convert the potential free energy of mixing sea and river water into electric ...
Sales, Bruno B, Schaetzle, Olivier, Schaetzle, O., Liu, Fei, Buisman, Cees JN, Sales, B.B., Hamelers, Hubertus VM, Burheim, O.S., Burheim, Odne S, Hamelers, H.V.M., Liu, F., Buisman, C.J.N.   +11 more
core   +1 more source

Integrated Triboelectric Nanogenerators in the Era of the Internet of Things

Advanced Science, 2019
Since their debut in 2012, triboelectric nanogenerators (TENGs) have attained high performance in terms of both energy density and instantaneous conversion, reaching up to 500 W m−2 and 85%, respectively, synchronous with multiple energy sources and ...
Abdelsalam Ahmed, Islam Hassan, Maher F. El‐Kady, Ali Radhi, Chang Kyu Jeong, Ponnambalam Ravi Selvaganapathy, Jean Zu, Shenqiang Ren, Qing Wang, Richard B. Kaner   +9 more
doaj   +1 more source

Power from the oceans: Blue energy [PDF]

Nature, 2014
After years in the doldrums, the quest to harvest energy from the oceans is gathering speed.
openaire   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Blue Energy : Een studie naar de haalbaarheid van Blue Energy

, 2007
Al vanaf de jaren ’70 van de vorige eeuw zijn er stemmen die zeggen dat binnen enkele decennia olie niet meer op een rendabele manier uit de groend gehaald kan worden.
Bouter, B.
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