Results 111 to 120 of about 6,322,087 (352)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Blue Light Therapy: A Skin Treatment Mask using Blue Light to cure Skin Disorders

Sukkur IBA Journal of Emerging Technologies
Skin acne and disease are the most common medical conditions that lead from mild to moderate if not treated in time. There are several treatments such as Chemical peel, Dermabrasion, and many others these hyped techniques have proven to be extremely ...
Aleena Kamal, Minahil Kamal, Bushra Mehboob, Tayaba Naz, Shoaib Zafar, Syed Muddusir Hussain   +5 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Effect of green light on nitrate reduction and edible quality of hydroponically grown lettuce (Lactuca sativa L.) under short-term continuous light from red and blue light-emitting diodes

Environmental and Experimental Botany, 2018
Most leafy vegetables can accumulate large amounts of nitrate, which are often associated with harmful effects on human health. Nitrate assimilation in plants is determined by various growth conditions, especially light conditions including light ...
Z. Bian, R. Cheng, Yu Wang, Qichang Yang, Chungui Lu   +4 more
semanticscholar   +1 more source

Dendrimer light-emitting diodes

, 2008
The electronics industry today is one that stands as a multi-billion dollar industry that is increasingly incorporating more and more products that have ever escalating applications in our everyday life.
Stevenson, Stuart G.
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Genetic and Molecular Characterization of a Cryptochrome from the Filamentous Fungus Neurospora crassa [PDF]

, 2010
In plants and animals, cryptochromes function as either photoreceptors or circadian clock components. We have examined the cryptochrome from the filamentous fungus Neurospora crassa and demonstrate that Neurospora cry encodes a DASH-type cryptochrome ...
Belden, William J.,, Jennifer J. Loros, Roenneberg, Till, Merrow, Martha,, Froehlich, Allan C., Dunlap, Jay C., Allan C. Froehlich, Merrow, Martha, Till Roenneberg, Loros, Jennifer J.,, Dunlap, Jay C.,, William J. Belden, Loros, Jennifer J., Roenneberg, Till,, Belden, William J., Cornelia Madeti, Madeti, Cornelia,, Froehlich, Allan C.,, Martha Merrow, Chen-hui Chen, Chen, Chen-Hui,, Madeti, Cornelia, Chen, Chen-Hui, Jay C. Dunlap   +23 more
core   +1 more source

Microalgae-based dosimetry for monitoring blue light exposure

Applied Phycology
Blue light therapy is increasingly used to treat various skin conditions like acne, psoriasis and neonatal hyperbilirubinemia. Yet, excessive blue light exposure can also negatively impact human health by disrupting circadian rhythms, generating free ...
Léa Habib, Jihane Rahbani Mounsef, Rime Michael-Jubeli, Marie Abboud, Ali Tfayli, Roger Lteif   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source