Results 41 to 50 of about 6,409,578 (294)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Transduction of Blue-Light Signals [PDF]
Plant Physiology, 1993 BUT IS IT AN ELEPHANT? In the old tale, several blind men are taken to an elephant. In turn, each is asked to examine and identify the mystery object. One blind man examines a leg and claims it to be a tree, another, examining the trunk, claims it to be a snake, and yet another, feeling a tusk, claims it to be a smooth rock. The pattern continues: each
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Frontiers in Plant ScienceIntroductionFar-red (FR; 700–800 nm) light and the difference between day and night temperature (DIF) interactively regulate plant morphology and growth. FR light and +DIF synergistically promote stem elongation, often reducing leaf expansion and overall
Awais Ali +7 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2018 Light emitting diodes (LEDs) are widely used to provide illumination due to their low energy requirements and high brightness. However, the LED spectrum contains an intense blue light component which is phototoxic to the retina.
Jia-Yu Li +12 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Plants, 2021 For 10 days before harvest, supplemental 50 μmol m−2 s−1 blue light (430 nm) was applied in greenhouse conditions in order to evaluate the influences of pre-harvest supplemental blue light on both antioxidants and nutrition of the flower stalk of Chinese
Haozhao Jiang +3 more
doaj +1 more source
Quantifying the properties of a dosimeter responsive to blue light hazard effective wavelengths [PDF]
, 2014 The research reported in this dissertation characterizes the properties of a proposed blue light dosimeter suitable for measuring the ocular blue light hazard.
Abudabous, Om Shanaf
core +1 more source