Results 51 to 60 of about 314,842 (260)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Leucomethylene blue staining during vagotomy
Journal of British Surgery, 1981 Abstract Sixty patients were evaluated 10 years after vagotomy for duodenal ulcer. In 31 the stain leucomethylene blue had been used peroperatively to visualize remaining nerve twigs on the distal oesophagus when the surgeon had deemed the vagotomy to be complete and in 29 cases the staining technique was not used.
P, Wille-Jørgensen, H E, Jensen
openaire +2 more sources
Performance of thermally modified timber (TMT) in outdoor application – durability, abrasion and optical appearance [PDF]
Drvna Industrija, 2009 Thermally modified timber (TMT) is increasingly offered in Europe as an alternative to preservative treated timber. TMT durability in field tests as well as its moisture sorption behaviour in façade application was determined so as to consider its ...
Christian R. Welzbacher +4 more
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Jurnal Penelitian Hasil Hutan (Journal of Forest Products Research), 2017 Freshly cut logs of tusam (Pinus merkusii) are very susceptible to the infestation of the ambrosia beetle Xyleborus sp. and blue stain fungi. An observation showed that both wood deteriorating organisms might infest a same log simultaneously, but they ...
Paimin Sukartana
doaj +3 more sources
Properties of blue-stained wood
Drvna Industrija, 2008 Discoloration of wood is frequently caused by blue-stain fungi. Among them Aureobasidium pullulans and Sclerophoma pithyophila are reported as the most important staining organism. In previous researches, it was generally considered that blue-stain fungi
Miha Humar, Viljem Vek, Bojan Bučar
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
The staining of fat by Nile‐blue sulphate [PDF]
The Journal of Pathology and Bacteriology, 1911 n ...
openaire +2 more sources
Efficacy of in-house fluorescent stain for fungus
Indian Journal of Pathology and Microbiology, 2017 Context: Mycotic infections are gaining importance in the present day medicine, and definite demonstration of fungus is essential for diagnosis. Small numbers of organisms in the smear can be identified by fluorescence microscopy.
K. R. L. Surya Kirani, V Satya Chandrika
doaj +1 more source