Results 161 to 170 of about 670,544 (383)

PP2A Promotes the Symmetric Division of MUC1‐Dominant Cancer Stem‐Like Cells in Small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
During the G2/M phase, mucin1 (MUC1) activates protein phosphatase 2A (PP2A), leading to reduced phosphorylation of protein kinase C ζ (PKCζ) and NUMB, which promotes symmetric division and expansion of cancer stem‐like cells (CSLCs), thereby driving tumorigenesis. Combined inhibition of the MUC1–PP2A axis using LB100/GO203 with etoposide restores PKCζ
Shengze Li   +15 more
wiley   +1 more source

Experimental flow properties in the wake of a 120 deg cone at Mach number 2.20 [PDF]

open access: yes
Supersonic flow characteristics in wake of blunt ...
Campbell, J. F., Grow, J. W.
core   +1 more source

Assembling Hexahedral Supramolecular Nano‐Aggregates on Rice Wax Layer Matrices to Promote the Leaf Deposition and Bioavailability of Bactericides for Plant Protections

open access: yesAdvanced Science, EarlyView.
To address the problem of off‐target movement and low bioavailability of pesticides, two anisotropic supramolecular building units (BiTA18@β‐CD and BiTA18@γ‐CD) have been invented that can self‐assemble into nano‐sized hexagonal cuboids on the rice microcrystalline matrix. This manipulation realizes the enhanced utilization of bactericides for rice and
Run Yang   +4 more
wiley   +1 more source

Blunt to sharpened razor [PDF]

open access: yes
"A key objective of China's reform program was to reduce distortions in the economic system and enhance growth. However, when implemented in incremental and partial ways, local governments or individuals have chance to capture rents inherent in the ...
Tan, Kong-Yam, Zhang, Xiaobo
core  

Evaluation of muscle nutritional value and flavor quality between triploid and diploid blunt snout bream (Megalobrama amblycephala): Applications of breeding improvement in fish quality

open access: yesAquaculture Reports
This study was to investigate the variances in muscles nutritional value and flavor quality between diploid (DBSB) and triploid blunt snout bream (Megalobrama amblycephala) (TBSB) muscles. Under the same culture conditions, the crude protein level, total
Xiao-Lei Su   +3 more
doaj  

A ROS‐Responsive Dual‐Targeting Drug Nanocarrier Serving as a GSI Synergist and Ferroptosis Sensitizer for T‐Cell Acute Lymphoblastic Leukemia

open access: yesAdvanced Science, EarlyView.
A self‐assembling nanotherapeutic strategy is designed—CD38‐PHD/G‐NPs, which released γ‐secretase inhibitor first, followed by adaptive dihydroartemisnin release in response to elevated reactive oxygen species levels. This controlled, sequential release strategy maximizes the synergistic anti‐leukemic efficacy of two agents with distinct mechanisms of ...
Ruinan Jia   +9 more
wiley   +1 more source

The effects of shock layer radiation and viscous coupling on the total heating rate to a reentering blunt body [PDF]

open access: yes
Coupling radiative and convective heat transfer in hypersonic blunt body ...
Engel, C. D., Spradley, L. W.
core   +1 more source

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