Results 21 to 30 of about 286,241 (363)

Oncolytic Adenovirus Armed with a Novel Agonist of the CD137 Immune Checkpoint Stimulator Suppresses Tumor Growth

open access: yesVaccines
Natural 4-1BBL (CD137L) is a cell membrane-bound protein critical to the expansion, effector function, and survival of CD8+ T cells. We reported the generation of an active soluble oligomeric construct, SA-4-1BBL, with demonstrated immunoprevention and ...
Martin R. Ramos-Gonzalez   +7 more
doaj   +1 more source

NFκB signaling in T cell memory

open access: yesFrontiers in Immunology, 2023
Memory T cells play an essential role in protecting against infectious diseases and cancer and contribute to autoimmunity and transplant rejection. Understanding how they are generated and maintained in the context of infection or vaccination holds ...
Mark A. Daniels   +7 more
doaj   +1 more source

Treatment strategy for acute blunt traumatic abdominal wall injury: a single-center retrospective study in Korea [PDF]

open access: yesJournal of Trauma and Injury
Purpose Traumatic abdominal wall hernia, a rare condition resulting from blunt trauma, is characterized by disruption of the abdominal wall musculature and fascia without skin penetration.
Gun Woo Kim   +4 more
doaj   +1 more source

Interference Mitigation for GNSS Receivers Using FFT Excision Filtering Implemented on an FPGA

open access: yesEng, 2022
GNSS receivers process signals with very low received power levels (
Tasneem Yousif, Paul Blunt
doaj   +1 more source

Evaluation of small-volume (3 ml) ophthalmic anaesthesia for both subtenon anaesthesia using blunt-tipped curved needle and single medial canthal injection with sharp needle for phacoemulsification surgery

open access: yesJournal of the Egyptian Ophthalmological Society, 2018
Introduction Medial canthus injection as well as subtenon anaesthesia has been used in anterior segment surgery. In this research, we compared the effectiveness and safety of small volume (3 ml) for either technique. Patients and methods Forty eyes of 40
Tamer A Refai, Rehab S Khattab
doaj   +1 more source

A Novel Single Differencing Measurement for Multipath Detection

open access: yesRemote Sensing, 2023
Increased global dependence on Global Navigation Satellite Systems (GNSSs) has resulted in a high demand for greater precision and reliable measurements from GNSS receivers. The multipath problem is the single largest source of errors in modernised GNSSs.
Matthew Alcock, Paul Blunt
doaj   +1 more source

Kinetic energy less lethal weapons and their associated blunt trauma injuries [PDF]

open access: yes, 2010
A widely used class of Less Lethal Weapon is the kinetic energy projectile. This can cause blunt trauma to the targeted person and, under certain circumstances, its use can result in permanent injury or death.
Tawell, Miles G.
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The NF-κB signaling network in the life of T cells

open access: yesFrontiers in Immunology
NF-κB is a crucial transcription factor in lymphocyte signaling. It is activated by environmental cues that drive lymphocyte differentiation to combat infections and cancer.
Mark A. Daniels   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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