Results 101 to 110 of about 207,082 (368)

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Injectable Chondroitin Sulfate Methacrylate Hydrogel Microspheres Co‐Loaded with GLPM Nanozyme, Dexamethasone, and Stem Cells for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
A multifunctional injectable microsphere system is fabricated via UV‐assisted microfluidic cross‐linking, integrating nanozyme‐based ROS scavenging, sustained dexamethasone release, and stem cell delivery. Upon IA injection, the microspheres adapt to joint stress, suppress inflammation, and promote cartilage regeneration, offering a minimally invasive ...
Xiaochen Feng, Ying Fang, Hongwei Yu, Yicheng Wang, Yunze Xu, Chunxiao Shi, Haike Xia, Ranjith Kumar Kankala, Aizheng Chen, Shibin Wang, Chaoping Fu   +10 more
wiley   +1 more source

Biomechanical Computed Tomography analysis (BCT) for clinical assessment of osteoporosis. [PDF]

, 2020
The surgeon general of the USA defines osteoporosis as "a skeletal disorder characterized by compromised bone strength, predisposing to an increased risk of fracture." Measuring bone strength, Biomechanical Computed Tomography analysis (BCT), namely ...
Bouxsein, ML, Clarke, BL, Cosman, F, Keaveny, TM, Khosla, S, Orwoll, ES, Siris, ES   +6 more
core  

Micro-CT Characterization of Human Trabecular Bone in Osteogenesis Imperfecta [PDF]

, 2011
Osteogenesis imperfecta (OI) is a genetic syndrome affecting collagen synthesis and assembly. Its symptoms vary widely but commonly include bone fragility, reduced stature, and bone deformity.
Albert, Carolyne, Harris, Gerald F, Jameson, John, Molthen, Robert C., Smith, Peter   +4 more
core   +2 more sources

Comparative Evaluation of Vitek®2 and BMD for Colistin Susceptibility in GNB isolated from ICU patients [PDF]

, 2023
Thripthi Ananda, K.E. Vandana, Chiranjay Mukhopadhyay   +2 more
openalex   +1 more source

Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes

Advanced Science, EarlyView.
In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu, Wenpin Qin, Jialu Gao, Yihan Guo, Xiaoxiao Han, Zhangyu Ma, Xiaokang Zhang, Jie He, Jing Liu, Bo Gao, Changjun Li, Lina Niu, Jianfei Yan, Kai Jiao   +13 more
wiley   +1 more source

Relation between bone mineral density and IL-17 serum levels in Serbian patients with early Rheumatoid arthritis

Open Medicine, 2014
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial inflammation and destruction of joint cartilage and bone. Different cytokines play important role in the processes that cause articular destruction and extra-articular ...
Pavlovic Voja, Dimic Aleksandar, Milenkovic Sasa, Krtinic Dane, Aleksic Ivana   +4 more
doaj   +1 more source

Fracture risk prediction: importance of age, BMD and spine fracture status

BoneKEy Reports, 2013
Our purpose was to identify factors for a parsimonious fracture risk assessment model considering morphometric spine fracture status, femoral neck bone mineral density (BMD) and the World Health Organization (WHO) clinical risk factors.
J. Krege, X. Wan, Brian C Lentle, C. Berger, L. Langsetmo, J. Adachi, Jerilynn C. Prior, A. Tenenhouse, Jacques P. Brown, N. Kreiger, W. Olszynski, R. Josse, D. Goltzman, David Nancy Alan Suzanne Silvia Claudie Wei Carol Christ Goltzman Kreiger Tenenhouse Godmaire Dumont Berger, D. Goltzman, Suzanne Godmaire, S. Dumont, C. Berger, W. Zhou, C. Joyce, C. Kovacs, E. Sheppard, S. Kirkland, S. Kaiser, B. Stanfield, Jacques P. Brown, Louis Bessette, M. Gendreau, T. Anastassiades, T. Towheed, Barbara Matthews, B. Josse, S. Jamal, T. Murray, Barbara Gardner-Bray, J. Adachi, A. Papaioannou, L. Pickard, W. Olszynski, K. Davison, Jola Thingvold, D. Hanley, Jane Allan, Jerilynn C. Prior, M. Patel, Y. Vigna, Nerkeza Andjelic, Brian C Lentle   +47 more
semanticscholar   +1 more source

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, EarlyView.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source

Anticonvulsants impacting bone metabolism: interim results from a cross-sectional study

Эпилепсия и пароксизмальные состояния
Background. Despite a wide range of antiepileptic drugs (AEDs) with an improved pharmacological profile, patients often experience a variety of side effects during long-trem anticonvulsant therapy, among which are osteoporotic disorders.
N. A. Sivakova, I. V. Abramova, I. Yu. Trukhina, V. P. Rybasova, E. D. Kasyanov, L. V. Lukina, V. A. Mikhailov, G. E. Mazo   +7 more
doaj   +1 more source