Results 81 to 90 of about 9,352,890 (302)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Minutes of the meeting of the Western Health Board 2nd July 1984
, 1984 Minutes of the regular Western Health Board meetings, held in ...
Western Health Board (WHB)
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Columbia Accident Investigation Board Report: Volume 1 [PDF]
, 2003 First volume of the final report produced by the Columbia Accident Investigation Board including the details of the Board's seven month investigation into the February 1, 2003 loss of the Space Shuttle Columbia. It includes sections on the accident, why
Columbia Accident Investigation Board
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
BulB - visualizing bulletin board activity [PDF]
, 2004 Visualisation is well known as an effective means of enriching user interaction with complex systems. Recent research with online communities has considered the application of visualisation tool support, with the intention of further improving communication between community members. This paper reviews existing work in this area with specific reference
Mohamed, R. +5 more
openaire +2 more sources
Minutes of the meeting of the Western Health Board 22nd March 1984
, 1984 Minutes of the regular Western Health Board meetings, held in ...
Western Health Board (WHB)
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Board characteristics and integrated reporting in an emerging market: evidence from India [PDF]
AJAR (Asian Journal of Accounting Research)Purpose – This paper aims to examine the influence of board characteristics on the integrated reporting quality (IRQ) of Indian-listed companies. Design/methodology/approach – The study uses a sample of 197 firms from the BSE 500 for the years 2017–2018 ...
Manimore Makri +2 more
doaj +1 more source
Health Research Board Annual Report Part 2: Corporate Governance 2022 and Financial Statements [PDF]
Te Board of the Health Research Board (HRB) was established under Te Health Research Board (Establishment) Order 1986 (S.I. NO.279 of 1986) as amended. Te functions of the HRB are set out in Article 4 of this statutory instrument.
Health Research Board
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source