Results 101 to 110 of about 454,846 (310)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Reply to 'Response: board composition and firm performance: evidence from Bangladesh - a sceptical view' [PDF]
, 2012 This paper replies to Chowdhury's (2010) response to the paper 'Board Composition and Firm Performance: Evidence from Bangladesh' (2010). It challenges the strength of the criticisms, arguing that the factors discussed in Chowdhury (2010) do not ...
De Zoysa, Anura +3 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Board of Director Monitoring and Firm Value in REITs [PDF]
This article examines the influence of board of director composition and characteristics on real estate investment trust (REIT) shareholder wealth as measured by firm market-to-book ratios.
H. Swint Friday, G. Stacy Sirmans
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Board Independence and Firm Financial Performance: Evidence from Nigeria [PDF]
This study examined the relationship between board independence and firm financial performance, using data of varying sample size (ranging from 89 firms for regression to 205 firms for descriptive analysis) obtained from the Nigerian Stock Exchange for ...
Ahmadu U. Sanda
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Councils of Kansas Board of Regents
, 2016 This document lists titles and composition of Kansas Board of Regents (KBOR) councils : Council of Presidents; System Council of Presidents; Council of Business Officers (COBO) & System Council of Business Officers (SCOBO); Council of Chief Academic ...
Kansas Board of Regents
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Kvotering i styrer: Effekter, tilpasninger og utfordringer etter innføring av ny regulering
MagmaDenne studien undersøker hvordan norske virksomheter tilpasser seg den nye kvoteringsreguleringen for styrer, som ble innført fra og med 2025 og gradvis skal gjelde for nærmere 20 000 selskaper fram mot 2028.
Eskil Sønju Le Bruyn +3 more
doaj +1 more source