Results 111 to 120 of about 454,846 (310)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Board structure, ownership structure and firm performance: A study of New Zealand listed-firms

, 2012
This paper investigates the role of board structure and the effect of ownership structures on firm performance in New Zealand's listed firms. Several studies, the majority from the U.S., U.K.
Fauzi, Fitriya, Locke, Stuart
core  

Do CEO attributes matter in the nexus between board composition and cybersecurity risk disclosure? Evidence from South African firms

Journal of Economic Criminology
In recent years, regulatory authorities, shareholders, managers, and governance bodies have been more aware of the growing wave of cyber threats and information security breaches and their effects on business operations. Cybersecurity risk disclosure has
Titus Ayobami Ojeyinka, Folorunsho M. Ajide, Reon Matemane   +2 more
doaj   +1 more source

Composition of the boards of Polish joint stock companies [PDF]

Management, 2007
The object of our research was the composition of Management Boards, Supervisory Boards and commercial representatives of all Polish joint stock companies. We have constructed an Internet accessible database in which analysed data are collected. We used MySQL database PHP scripts and Apache server.
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The Effect of Board Structure on Bidder-Shareholders' Wealth: Further Evidence from the UK Bidding Firms [PDF]

In this study we provide evidence of cross-sectional dependence of bidder-shareholder wealth and target’s board characteristics. More specifically we provide evidence that the percentage of non-executives, the board size, the stock holdings of executives,
Costas Th. Constantinou, Charalambos Th. Constantinou   +1 more
core  

Board Characteristics Best Practices and Financial Performance. Evidence from the European Capital Market

Amfiteatru Economic, 2014
This study investigates board characteristics best practices in the particular context of European listed companies. The theoretical grounding of the paper is done by discussing board composition and board compensation related studies, mainly belonging ...
Victor-Octavian Müller, Ionel-Alin Ienciu, Carmen Giorgiana Bonaci, Crina Ioana Filip   +3 more
doaj  

Determinants of agency cost: Evidence from listed real estate firms on the Vietnam Stock Exchange

Ho Chi Minh City Open University Journal of Science - Economics and Business Administration
This study investigates the impact of corporate governance factors on agency problems in 42 listed real estate companies on the Vietnam stock exchange from 2013 to 2023, utilizing 462 observations and the Feasible Generalized Least Squares (FGLS) model.
Tuan Anh Nguyen, Thi Thuy Dung Tran, Tuan Anh Vuong   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source