Results 121 to 130 of about 1,574,881 (361)

In the boardroom spotlight: Examining the relationship between board size and profitability in Turkish family businesses with independent directors as key players

open access: yes
This paper investigates the intricate relationship between board composition, particularly the number of independent members, and the return on assets (ROA) in Turkish listed family businesses. Building upon existing literature on family firm management,
Kamran Jannatli
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Board of directors' characteristics and conditional accounting conservatism : Spanish evidence. [PDF]

open access: yes
Using a sample of Spanish listed firms for the period 1997-2002 we find that firms where the CEO has low influence over the functioning of the board of directors show a greater degree of accounting conservatism.
García Osma, Beatriz   +2 more
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Exploring the Cognitive Nature of Boards of Directors and Its Implication for Board Effectiveness [PDF]

open access: yes
In this paper we propose a theoretical framework that emphasizes the development of a shared mental model (SMM) of a board of directors and its impact on board effectiveness and suggest that the accuracy and scope of the SMM in a board will moderate the ...
John E. Prescott   +2 more
core  

Investigating absorptive capacity in boards, corporate governance and the value creating board [PDF]

open access: yes, 2013
A thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of Philosophy.Within corporate governance research, boards of directors constitute an essential part and are described as "the apex ...
Schonning, Aud Randi
core  

Not size but attributes: the relationship between board attributes and cash holdings

open access: yesCogent Business & Management
This study examines the attributes of board members and the role of board size as a governance factor in determining corporate cash holdings. Our findings indicate that the age and tenure of board members jointly have a positive impact on firms’ cash ...
Kemakorn Chaiprasit   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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