Results 71 to 80 of about 835,924 (260)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Dreamy Dwellings: How the Sleep Environment Affects Sleep Health in Adults—A Narrative Review

Lifestyle Medicine
Sufficient high‐quality, well‐timed sleep is essential to health and physical, cognitive and emotional functions. Historically, environmental factors such as threats from other beings have likely constrained sleep.
Gregory David Maxwell Potter, Gregory J. Grosicki, Grant M. Tinsley, Thomas R. Wood, Dan Garner, Andrew J. Galpin   +5 more
doaj   +1 more source

Balancing energy expenditure and body weight [PDF]

The American Journal of Clinical Nutrition, 1998
It has been nearly 50 y since Mayer and coworkers hypothesized that the mechanisms controlling energy balance are accurate in persons with high levels of physical activity, but that in sedentary persons there is a threshold of physical activity below which these mechanisms become imprecise and that this leads to obesity.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Features of body balance in 12-year-old schoolchildren with visual deprivation compared to their relatively healthy peers

Фізична реабілітація та рекреаційно-оздоровчі технології
Purpose. The purpose of the presented scientific research was to carry out a comparative analysis of the state of functional balance of the body of 12-year-old schoolchildren with visual deprivation in accordance with their relatively healthy peers ...
Bozhena Bukhovets, Vitalii Kashuba, Boris Dolinskiy, Olena Pogorelova, Volodymyr Boboshko   +4 more
doaj   +1 more source

Evaluation of influence of stretching therapy and ergonomic factors on postural control in patients with chronic non-specific low back pain

Annals of Agricultural and Environmental Medicine, 2015
Introduction The vertical orientation of the body in the upright standing position is maintained by keeping the body’s centre of gravity (COG) upright, above the base of support, by a dynamic interplay of visual, vestibular, and somatosensory control ...
Piotr Gawda, Magdalena Dmoszyńska-Graniczka, Halina Pawlak, Marek Cybulski, Michał Kiełbus, Piotr Majcher, Agnieszka Buczaj, Marcin Buczaj   +7 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source