Results 101 to 110 of about 2,117,813 (293)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Color Instrument Analysis of Octopus Drying Using Solar Hybrid Dryer [PDF]

BIO Web of Conferences
Octopus drying in Kaur Regency, Bengkulu Province, is done by direct sun drying. It causes low color quality due to UV light. Solar hybrid drying with UV protection is needed to control the color quality of the octopus.
Fatharani Arina, Maissy Faulina, Yuwana Yuwana, Anis Ulfah   +3 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Analysis and explanation of Sadr al-Mutalahin's view about the truth of visible light [PDF]

حکمت صدرایی
Discussing and examining categories and their types is always considered as one of the most important topics among philosophical issues. Bag category is one of these ten categories. This category includes different types, of which the tangible bag is one
hamidreza khademi, reza hesari
doaj   +1 more source

Stability of pentaquarks with a two- plus three-body chromoelectric interaction

, 2017
We study the stability of pentaquarks within a schematic model based on SU(3) color symmetry, by taking into account algebraic arguments leading to a chromoelectric interaction containing two- and three-body parts. It has already been proven that such an
Stancu, Fl.
core   +1 more source

Color and the Mind-Body Problem

Dialectica, 2006
Other philosophical traditions can offer a new perspective on our own ingrained and prejudicial habits of thinking. The insular, decontextualized, acultural analytic philosophy of today, with its emphasis on language, truth, and logic, needs to adopt a more pluralistic approach. In particular, philosophical traditions in other possible worlds have been
openaire   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

Neutron stars and the transition to color-superconducting quark matter

, 2003
We explore the relevance of color superconductivity inside a possible quark matter core for the bulk properties of neutron stars. For the quark phase we use an Nambu--Jona-Lasinio (NJL) type model, extended to include diquark condensates.
Alford, Alford, Alford, Alford, Alford, Baldo, Baldo, Baldo, Baldo, Baldo, Bedaque, Blaschke, Buballa, Buballa, Carlson, F. Neumann, G.F. Burgio, Glendenning, H.-J. Schulze, Huang, Hulse, Lacombe, M. Baldo, M. Buballa, M. Oertel, Maessen, Neumann, Rajagopal, Rapp, Rehberg, Schertler, Schiavilla, Shovkovy, Song, Song, Steiner, Steiner, Vidaña   +37 more
core   +3 more sources