Results 101 to 110 of about 866,812 (308)

استفاده از شاخص‌های تن‌سنجی در طراحی معادلات پیشگوی تخمین چربی کل بدن جهت حذف اسکن دگزا از کل بدن

مجله دانشکده پزشکی اصفهان, 2014
مقدمه: هدف از این مطالعه، پیش‌بینی کل بافت چربی با استفاده از متغیرهای تن‌سنجی (اندازه‌ی دور کمر، اندازه‌ی دور باسن، نسبت دور کمر به باسن، نسبت دور کمر به قد و شاخص توده‌ی بدنی) بود.
Mohammad Reza Salamat, Ahmad Shanei, Mahdi Asgari, Amirhossein Salamat, Mehri Khoshhali   +4 more
doaj  

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Impact of liposomal delivery on coenzyme Q10 absorption: a double-blind, placebo-controlled, randomized trial

Frontiers in Nutrition
BackgroundCoenzyme Q10 (CoQ-10) plays a vital role in cellular energy production and protection against oxidative stress. However, its absorption from orally administered forms is limited due to its poor water solubility and relatively large molecular ...
Ralf Jäger, Martin Purpura, Ashok Godavarthi, Halil Ibrahim Ceylan, Sebastian T. Balcombe, Ambrish Chandrappa, Grant M. Tinsley   +6 more
doaj   +1 more source

Urinary Incontinence in Older Women: The Role of Body Composition and Muscle Strength: From the Health, Aging, and Body Composition Study

, 2016
Anne M. Suskind, Peggy M. Cawthon, Sanae Nakagawa, Leslee L. Subak, Ilse Reinders, Suzanne Satterfield, Steve Cummings, Jane A. Cauley, Tamara Harris, Alison J. Huang, Health ABC Study   +10 more
openalex   +1 more source

Impact of Body Composition in Overweight and Obese Patients With Localised Renal Cell Carcinoma [PDF]

, 2020
Tiffany Darbas, Géraud Forestier, Sophie Léobon, Julia Pestre, Pierre Jésus, Denis Lachâtre, N. Tubiana-Mathieu, A. Descazeaud, Élise Deluche   +8 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Dreamy Dwellings: How the Sleep Environment Affects Sleep Health in Adults—A Narrative Review

Lifestyle Medicine
Sufficient high‐quality, well‐timed sleep is essential to health and physical, cognitive and emotional functions. Historically, environmental factors such as threats from other beings have likely constrained sleep.
Gregory David Maxwell Potter, Gregory J. Grosicki, Grant M. Tinsley, Thomas R. Wood, Dan Garner, Andrew J. Galpin   +5 more
doaj   +1 more source