Results 121 to 130 of about 2,673,790 (264)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Impact of liposomal delivery on coenzyme Q10 absorption: a double-blind, placebo-controlled, randomized trial

Frontiers in Nutrition
BackgroundCoenzyme Q10 (CoQ-10) plays a vital role in cellular energy production and protection against oxidative stress. However, its absorption from orally administered forms is limited due to its poor water solubility and relatively large molecular ...
Ralf Jäger, Martin Purpura, Ashok Godavarthi, Halil Ibrahim Ceylan, Sebastian T. Balcombe, Ambrish Chandrappa, Grant M. Tinsley   +6 more
doaj   +1 more source

Body composition of male and female Chilean powerlifters of varying body mass [PDF]

, 2019
Alvarez, Cristian, Cisterna, Diego, Hernandez, Jordan, Keogh, Justin W., Palma-Lafourcade, Patricio, Ramirez-Campillo, Rodrigo   +5 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Dreamy Dwellings: How the Sleep Environment Affects Sleep Health in Adults—A Narrative Review

Lifestyle Medicine
Sufficient high‐quality, well‐timed sleep is essential to health and physical, cognitive and emotional functions. Historically, environmental factors such as threats from other beings have likely constrained sleep.
Gregory David Maxwell Potter, Gregory J. Grosicki, Grant M. Tinsley, Thomas R. Wood, Dan Garner, Andrew J. Galpin   +5 more
doaj   +1 more source

Development of a sport specific anthropometric calibration model to estimate whole body density of professional football players [PDF]

There are currently no calibration models that allow whole body density in professional footballers to be estimated. As such, there is a need to develop practical calibration models in order to make sound body composition judgements.
Mills, Claire D
core  

The Production and Body Composition of Kacang Goat Fed Different Quality of Diets [PDF]

, 2013
An experimental study was carried out to assess the effect of diet quality on productivity and bodycomposition of Kacang goat. Fifteen male Kacang goats weighing 14.28 ± 3.36 kg (CV = 23.55%) weredivided into 5 groups based on body weight.
Purnomoadi, A. (A), Restitrisnani, V. (V), Rianto, E. (E)   +2 more
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Association between Dietary Practice and Gait Speed in Community-Dwelling Older Adults with Overweight and Obesity: A Cross-Sectional Study

Diseases
Slow gait speed is associated with poorer clinical outcomes and higher rates of functional limitation and mortality in older adults, especially when combined with overweight or obesity. Aging is also associated with nutritional deficits.
Leila Itani, Massimo Pellegrini, Dana Saadeddine, Hanen Samouda, Dima Kreidieh, Hana Tannir, Marwan El Ghoch   +6 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source