Results 161 to 170 of about 7,463,330 (288)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

The Correlation of Linear Body Size With Body Condition Score and Body Weight of Participated Cow Used in the Progeny Test in East Java

Animal Production: Indonesian Journal of Animal Production
This study aims to analyze the linear size of the bodies of participated cow used in the progeny test of dairy cows in KAN Jabung, Malang, East Java. The material used consisted of 180 lactating cows emplyed as participated cows.
Rizka Larasati Laras, Tri Eko Susilorini, Puguh Surjowardojo, Rini Dwi Wahyuni   +3 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Impact of Body Reserves Dynamic on Productivity and Reproductive Performance in Fat-Tail and Thin-Tail Sheep Breeds over Contrasting Production Cycles

Animals
Under climate change, animal breeding faces severe nutritional challenges, exhibiting their resilience and efficiency to survive and produce. The animals’ robustness can be evaluated through the use and reconstitution of body reserves (BR).
Yathreb Yagoubi, Samir Smeti, Mokhtar Mahouachi, Massara Nasraoui, Samia Ben Saïd, Aziza Mohamed-Brahmi, Naziha Atti   +6 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The importance of the body condition score of the dairy cow at dry-off and calving time: a farm analysis of the production and health impact on the early phase of the following lactation [PDF]

openPer consentire la massima espressione delle performance produttive delle bovine da latte è necessario combinare un eccellente patrimonio genetico ad un sistema di allevamento che, soddisfacendo appieno i fabbisogni dell’animale, sia in grado di ...
PIETROBON, MARTA
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Hubungan Produksi Susu Dengan Body Condition Score (Bcs) Ternak Sapi Perah Di Kecamatan Baturraden Kabupaten Banyumas [PDF]

, 2019
hubungan produksi susu dengan body condition score (bcs) ternak sapi perah di kelompok tani ternak margo mulyo, kecamatan baturraden, kabupaten banyumas. penelitian dilaksanakan pada tanggal 17 maret 2019 sampai dengan 26 mei 2019.
PUTRI, Rizkia Amanda
core