Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Persuasion as a social heuristic: A rhetorical analysis of the making of the constitution of Namibia
The study focuses on the rhetoric used during the drafting of the Constitution of the Republic of Namibia. The thesis will offer a framework for understanding negotiations in terms of distinct and coherent rhetoric.
Mathe, Audrin
core
Justifikasi Pelembagaan Peradilan Etik
This study examines the justification of institutionalize the court of ethic. This type of research is normative juridical. The approach used is a historical, statue, and conceptual approach. The results show that urgency of institutionalization court of
Idul Rishan
doaj +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Integrating Traditional Medicine to Improve the Care of Persistent Physical Symptom
Persistent physical symptom (PPS) is a common condition in sub‐healthy population and patients with chronic disease, and significantly influences the quality of life.
Huai‐Yu Wang, Ji Wang, Qi Wang
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A multilevel analysis of place effects on body constitution
Body constitution, according to Traditional Chinese Medicine (TCM), is an individual's personal state of health expressed in reference to body metabolism and susceptibility to pathogenic factors.
Lai, PC, Low, CT
core
TCM body constitution study of patients with hypertension
Hypertension is a global health concern. Traditional Chinese Medicine (TCM) is becoming popular and often used among hypertensive patients. Traditional Chinese Medicine Body Constitution (TCMBC) is part of the TCM concept.
Lim, Eileen Yuling
core
The Attempt to Human Rights Protection Through Judicial Review in Indonesia
The Constitutional Court is one of the perpetrators of judicial power, in addition to the Supreme Court as referred to in Article 24 paragraph (2) of the 1945 Constitution. The Constitutional Court is also bound to the general principle of an independent
Ardhanariswari Riris +2 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source

