Results 71 to 80 of about 783,329 (306)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Waist-to-Hip Ratio is Related to Body Fat Content and Distribution Regardless of the Waist Circumference Measurement Protocol, in Non-Alcoholic Fatty Liver Disease Patients [PDF]

, 2016
Central accumulation and distribution of body fat (BF) is an important cardiometabolic risk factor. Waist-to-hip ratio (WHR), commonly elevated in non-alcoholic fatty liver disease (NAFLD) patients, has been endorsed as a risk related marker of central ...
Cortez-Pinto, Helena, Melo, Xavier, Pimenta, Nuno, Santa-Clara, Helena, Sardinha, Luis, Silva Nunes, José António   +5 more
core   +1 more source

Waist Circumference and Waist-to-Hip Ratio in Law Enforcement Agency Recruits: Relationship to Performance in Physical Fitness Tests [PDF]

, 2020
Law enforcement agencies (LEAs) use tests to assess recruit physical fitness. Body fat can influence test performance but is difficult to measure during academy because of time, equipment constraints, and instructor knowledge.
Dawes, J Jay, Dulla, Joseph M, Lockie, Robert G, Orr, Robin M, Ruvalcaba, Tomas R, Stierli, Michael   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A Single Nucleotide Polymorphism in the FADS1 Gene is Associated with Plasma Fatty Acid and Lipid Profiles and Might Explain Gender Difference in Body Fat Distribution

Lipids in Health and Disease, 2017
Background Genotyping of the rs174547 polymorphism in the fatty acid desaturase 1 gene (FADS1) shows that it is associated with the FA composition of plasma phospholipids and lipid metabolic indices among several ethnic groups.
Huilan Guo, Lichao Zhang, Chaonan Zhu, Fei Yang, Shanshan Wang, Shankuan Zhu, Xiaoguang Ma   +6 more
doaj   +1 more source

Antropometriai paraméterek diagnosztikus hatékonysága az elhízás, különös tekintettel a zsigeri zsírfelhalmozódás és bizonyos kardiovaszkuláris rizikótényezők tükrében [PDF]

, 2015
Diagnostic efficiency of anthropometric parameters in the detection of obesity, with special regard to visceral adiposity and certain cardiovascular risk factors. The visceral adipose tissue carries greater risk of developing cardio-metabolic disorders
Pintér, Zoltán
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Pattern of body fat distribution in patients of PCOS using DEXA-based indices

Middle East Fertility Society Journal
Background Considering the close link between polycystic ovary syndrome (PCOS) and metabolic syndrome considerable research has been devoted to studying the pattern of fat distribution in PCOS.
Sanna Birjees, Majid Jehangir, Mirza Vamiq Rasool, Fiza Amin, Seema Qayoom   +4 more
doaj   +1 more source

Increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type 2 diabetes patients

Journal of Diabetes Investigation, 2021
Obesity is increasing in patients with type 2 diabetes. A possible reduced association between fructosamine and glycated hemoglobin (HbA1c) in obese individuals has been previously discussed, but this has never been specifically evaluated in type 2 ...
Bruno Vergès, Alexia Rouland, Sabine Baillot‐Rudoni, Marie‐Claude Brindisi, Laurence Duvillard, Isabelle Simoneau, Pauline Legris, Jean‐Michel Petit, Benjamin Bouillet   +8 more
doaj   +1 more source

Fat and water distribution patterns in the flesh of the common cat-fish Wallago attu (Bl. & Schn.) [PDF]

, 1973
The quantitative distributional pattern of fat and water has been studied in the flesh of the various zones corresponding to the dorsal and ventral regions of the body of a common cat-fish, Wallago attu.
Jafri, A.K.
core