Results 11 to 20 of about 7,158,834 (368)
Physiological Reports, 2020 Most of the filtered glucose is reabsorbed in the early proximal tubule by the sodium‐glucose cotransporter SGLT2. The glycosuric effect of the SGLT2 inhibitor ipragliflozin is linked to a diuretic and natriuretic effect that activates compensatory ...
Takahiro Masuda +7 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 Numerous studies indicate a significant role for cytochrome P-450-dependent arachidonic acid metabolites in blood pressure regulation, vascular tone, and control of renal function. Epoxyeicosatrienoic acids (EETs) exhibit a spectrum of beneficial effects,
Iwona Baranowska +10 more
doaj +1 more source
Factors affecting an increase in core body temperature and heat tolerance during hot water immersion
Journal of Physical Fitness and Sports Medicine, 2021 The aim of the present study was to clarify the factors affecting an increase in core body temperature during 40°C water immersion to the subclavian level. Fifteen healthy males were immersed in water for 60 min.
Yuta Masuda +2 more
doaj +1 more source
Calculating LRs for presence of body fluids from mRNA assay data in mixtures [PDF]
Forensic Science International: Genetics, Volume 52, 2021, 102455.
https://www.sciencedirect.com/science/article/pii/S1872497320302271, 2022 Messenger RNA (mRNA) profiling can identify body fluids present in a stain, yielding information on what activities could have taken place at a crime scene. To account for uncertainty in such identifications, recent work has focused on devising statistical models to allow for probabilistic statements on the presence of body fluids.
arxiv +1 more source
20 kDa PEGylated Adrenomedullin as a New Therapeutic Candidate for Inflammatory Bowel Disease
Gastrointestinal Disorders, 2020 Human adrenomedullin (AM), a hypotensive peptide, also has anti-colitis activity. We prepared a polyethylene glycol (PEG) ylated form of AM through the conjugation of PEG-AM (1–15) and AM (15–52).
Goro Miki +10 more
doaj +1 more source
Diabetology & Metabolic Syndrome, 2020 Background Sodium–glucose cotransporter 2 (SGLT2) inhibitors are an antihyperglycemic drug with diuretic action. We recently reported that the SGLT2 inhibitor dapagliflozin ameliorates extracellular volume expansion with a mild increase in urine volume ...
Ken Ohara +13 more
semanticscholar +1 more source
Human body-fluid proteome: quantitative profiling and computational prediction
Briefings Bioinform., 2020 Empowered by the advancement of high-throughput bio technologies, recent research on body-fluid proteomes has led to the discoveries of numerous novel disease biomarkers and therapeutic drugs. In the meantime, a tremendous progress in disclosing the body-
Lan Huang +6 more
semanticscholar +1 more source
Diagnostics, 2020 Although, DNA typing plays a decisive role in the identification of persons from blood and body fluid stains in criminal investigations, clarifying the origin of extracted DNA has also been considered an essential task in proving a criminal act.
Koichi Sakurada, Ken Watanabe, T. Akutsu
semanticscholar +1 more source
Levitation and dynamics of bodies in supersaturated fluids [PDF]
Nature Communications 15 (2024) 3910, 2023 A body immersed in a supersaturated fluid like carbonated water can accumulate a dynamic field of bubbles upon its surface. If the body is mobile, the attached bubbles can lift it upward against gravity, but a fluid-air interface can clean the surface of these lifting agents and the body may plummet.
arxiv +1 more source
Role of Body-Fluid Biomarkers in Alzheimer’s Disease Diagnosis
Diagnostics, 2020 Alzheimer’s disease (AD) is a complex neurodegenerative disease that requires extremely specific biomarkers for its diagnosis. For current diagnostics capable of identifying AD, the development and validation of early stage biomarkers is a top research ...
T. Nguyen +4 more
semanticscholar +1 more source