Results 11 to 20 of about 8,403,686 (346)

LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism

Frontiers in Pharmacology, 2021
Apelin is a neuro-vasoactive peptide that plays a major role in the control of cardiovascular functions and water balance, but has an in-vivo half-life in the minute range, limiting its therapeutic use.
Adrien Flahault, Mathilde Keck, Pierre-Emmanuel Girault-Sotias, Lucie Esteoulle, Nadia De Mota, Dominique Bonnet, Catherine Llorens-Cortes   +6 more
doaj   +1 more source

Early Renal Vasodilator and Hypotensive Action of Epoxyeicosatrienoic Acid Analog (EET-A) and 20-HETE Receptor Blocker (AAA) in Spontaneously Hypertensive Rats

Frontiers in Physiology, 2021
Cytochrome P450 (CYP-450) metabolites of arachidonic acid: epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) have established role in regulation of blood pressure (BP) and kidney function.
Agnieszka Walkowska, Luděk Červenka, Luděk Červenka, John D. Imig, John R. Falck, Janusz Sadowski, Elżbieta Kompanowska-Jezierska   +6 more
doaj   +1 more source

The Use of Simulated Body Fluid (SBF) for Assessing Materials Bioactivity in the Context of Tissue Engineering: Review and Challenges

Biomimetics, 2020
Some special implantable materials are defined as “bioactive” if they can bond to living bone, forming a tight and chemically-stable interface. This property, which is inherent to some glass compositions, or can be induced by applying appropriate surface
F. Baino, S. Yamaguchi
semanticscholar   +1 more source

Epoxyeicosatrienoic Acid Analog and 20-HETE Antagonist Combination Prevent Hypertension Development in Spontaneously Hypertensive Rats

Frontiers in Pharmacology, 2022
Numerous studies indicate a significant role for cytochrome P-450-dependent arachidonic acid metabolites in blood pressure regulation, vascular tone, and control of renal function. Epoxyeicosatrienoic acids (EETs) exhibit a spectrum of beneficial effects,
Iwona Baranowska, Iwona Baranowska, Olga Gawrys, Olga Gawrys, Agnieszka Walkowska, Krzysztof H. Olszynski, Luděk Červenka, John R. Falck, Adeniyi M. Adebesin, John D. Imig, Elżbieta Kompanowska-Jezierska   +10 more
doaj   +1 more source

Factors affecting an increase in core body temperature and heat tolerance during hot water immersion

Journal of Physical Fitness and Sports Medicine, 2021
The aim of the present study was to clarify the factors affecting an increase in core body temperature during 40°C water immersion to the subclavian level. Fifteen healthy males were immersed in water for 60 min.
Yuta Masuda, Issei Kato, Kei Nagashima   +2 more
doaj   +1 more source

Osmotic diuresis by SGLT2 inhibition stimulates vasopressin‐induced water reabsorption to maintain body fluid volume

Physiological Reports, 2020
Most of the filtered glucose is reabsorbed in the early proximal tubule by the sodium‐glucose cotransporter SGLT2. The glycosuric effect of the SGLT2 inhibitor ipragliflozin is linked to a diuretic and natriuretic effect that activates compensatory ...
Takahiro Masuda, S. Muto, Keiko Fukuda, Minami Watanabe, Ken Ohara, H. Koepsell, V. Vallon, D. Nagata   +7 more
semanticscholar   +1 more source

20 kDa PEGylated Adrenomedullin as a New Therapeutic Candidate for Inflammatory Bowel Disease

Gastrointestinal Disorders, 2020
Human adrenomedullin (AM), a hypotensive peptide, also has anti-colitis activity. We prepared a polyethylene glycol (PEG) ylated form of AM through the conjugation of PEG-AM (1–15) and AM (15–52).
Goro Miki, Nobuko Kuroishi, Mariko Tokashiki, Sayaka Nagata, Masaji Tamura, Taku Yoshiya, Kumiko Yoshizawa-Kumagaye, Shinya Ashizuka, Joji Kato, Motoo Yamasaki, Kazuo Kitamura   +10 more
doaj   +1 more source

The extracellular volume status predicts body fluid response to SGLT2 inhibitor dapagliflozin in diabetic kidney disease

Diabetology & Metabolic Syndrome, 2020
Background Sodium–glucose cotransporter 2 (SGLT2) inhibitors are an antihyperglycemic drug with diuretic action. We recently reported that the SGLT2 inhibitor dapagliflozin ameliorates extracellular volume expansion with a mild increase in urine volume ...
Ken Ohara, Takahiro Masuda, Masato Morinari, M. Okada, Atsushi Miki, Saki Nakagawa, Takuya Murakami, Kentaro Oka, Maki Asakura, Yasuharu Miyazawa, A. Maeshima, T. Akimoto, O. Saito, D. Nagata   +13 more
semanticscholar   +1 more source

Human body-fluid proteome: quantitative profiling and computational prediction

Briefings Bioinform., 2020
Empowered by the advancement of high-throughput bio technologies, recent research on body-fluid proteomes has led to the discoveries of numerous novel disease biomarkers and therapeutic drugs. In the meantime, a tremendous progress in disclosing the body-
Lan Huang, Dan Shao, Yan Wang, Xueteng Cui, Yufei Li, Qian Chen, J. Cui   +6 more
semanticscholar   +1 more source

Current Methods for Body Fluid Identification Related to Sexual Crime: Focusing on Saliva, Semen, and Vaginal Fluid

Diagnostics, 2020
Although, DNA typing plays a decisive role in the identification of persons from blood and body fluid stains in criminal investigations, clarifying the origin of extracted DNA has also been considered an essential task in proving a criminal act.
Koichi Sakurada, Ken Watanabe, T. Akutsu
semanticscholar   +1 more source