Results 31 to 40 of about 256,725 (297)

Biology of the Extracellular Proteasome

Biomolecules, 2022
Proteasomes are traditionally considered intracellular complexes that play a critical role in maintaining proteostasis by degrading short-lived regulatory proteins and removing damaged proteins. Remarkably, in addition to these well-studied intracellular
Gili Ben-Nissan, Naama Katzir, Maria Gabriella Füzesi-Levi, Michal Sharon   +3 more
doaj   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Comparison of Cell Preparations between Commercially Available Filter Cards of the Cytospin with Custom Made Filter Cards [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Cytological evaluation of body fluids is an important diagnostic technique. Cytocentrifuge has contributed immensely to improve the diagnostic yield of the body fluids.
Vani Krishnamurthy, Suchitha Satish, Srinivasa Murthy Doreswamy, Manjunath Gubbanna Vimalambike   +3 more
doaj   +1 more source

Organic Thin Film Transistor for Effective Biomarker Detection in Early Disease Diagnosis

Chemosensors, 2023
Recently, people are becoming more concerned about their physical health and putting forward higher requirements for an early and painless diagnosis of diseases.
Yifan Wang, Si Cheng, Chenfang Sun, Tie Wang   +3 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Exposição ocupacional a material biológico por pessoal de saúde: construção e proposição de instrumentos avaliativos

Revista Brasileira de Saúde Ocupacional
No Brasil, os indicadores de exposição aos agentes biológicos apresentam lacunas acerca dos conhecimentos, das atitudes e dos comportamentos do pessoal de saúde e não há instrumento validado para avaliação desses aspectos.
Paula Muniz do Amaral, José Tavares-Neto   +1 more
doaj   +1 more source

Environmental Stability and Infectivity of Hepatitis C Virus (HCV) in Different Human Body Fluids

Frontiers in Microbiology, 2018
Background: Hepatitis C virus (HCV) is a hepatotropic, blood-borne virus, but in up to one-third of infections of the transmission route remained unidentified.
Stephanie Pfaender, Stephanie Pfaender, Fabian A. Helfritz, Anindya Siddharta, Daniel Todt, Daniel Todt, Patrick Behrendt, Patrick Behrendt, Julia Heyden, Nina Riebesehl, Wiebke Willmann, Joerg Steinmann, Joerg Steinmann, Jan Münch, Sandra Ciesek, Eike Steinmann, Eike Steinmann   +16 more
doaj   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source