Results 91 to 100 of about 1,135,710 (273)

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

open access: yesFEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik   +3 more
wiley   +1 more source

Book review of “Here, there, everywhere—A memoir” by Peter Almond

open access: yes, 2022
Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022.
Bruce J. Gerbi
wiley   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

open access: yesFEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui   +15 more
wiley   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

open access: yesFEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren   +8 more
wiley   +1 more source

Separation of Body and Background in Radiological Images. A Practical Python Code [PDF]

open access: yesarXiv
Radiological images, such as magnetic resonance imaging (MRI) and computed tomography (CT) images, typically consist of a body part and a dark background. For many analyses, it is necessary to separate the body part from the background. In this article, we present a Python code designed to separate body and background regions in 2D and 3D radiological ...
arxiv  

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

open access: yesFEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu   +6 more
wiley   +1 more source

Structure-Guided MR-to-CT Synthesis with Spatial and Semantic Alignments for Attenuation Correction of Whole-Body PET/MR Imaging [PDF]

open access: yesarXiv
Deep-learning-based MR-to-CT synthesis can estimate the electron density of tissues, thereby facilitating PET attenuation correction in whole-body PET/MR imaging. However, whole-body MR-to-CT synthesis faces several challenges including the issue of spatial misalignment and the complexity of intensity mapping, primarily due to the variety of tissues ...
arxiv  

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