Results 91 to 100 of about 15,310,299 (303)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Developing a Positive Body Image in Young Women by the Means of Training Technologies

Консультативная психология и психотерапия, 2019
The paper presents the analysis of the positive body image formation among young women, characterizes determinants of female body image and describes the results of an experimental study. The purpose of the study was to test the possibility of developing
Belogai K.N., Morozova I.S., Kagan E.S., Gubanova M.I., Borisenko Yu.V.   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Acceptance and commitment therapy to reduce eating disorder symptoms and body image problems in patients with residual eating disorder symptoms : A randomized controlled trial

, 2020
Body image problems are central aspects of eating disorders (ED), and risk factors both for the development of and relapse into an ED. Acceptance and commitment therapy (ACT) aims at helping patients accept uncomfortable internal experiences while ...
Parling, Thomas,, Kjellin, Lars,, Gustafsson, Sanna Aila,, Parling, T,, Fogelkvist, M, Fogelkvist, Maria,, Kjellin, L, Gustafsson, SA   +7 more
core   +1 more source

Unexcused absence from physical education in elementary school. On the role of autonomous motivation and body image factors.

, 2023
Physical education (PE) is an essential school subject due to its potential to promote well-being and health in all children. Yet, PE stands out among other subjects in terms of truancy. This study is one of the first to examine if unexcused absence from
Skoog, Therése,, Carolina Lunde, Tommy Reinholdsson, Therése Skoog, Lunde, Carolina,, Reinholdsson, Tommy, Lunde, Carolina, Reinholdsson, Tommy,, Skoog, Therése   +8 more
core   +1 more source

Body Image Avoidance, Body Dissatisfaction, and Eating Pathology

American Journal of Men's Health, 2016
With research highlighting the increasing prevalence and severity of body image and eating disturbances in males, particularly athletes and regular gymnasium users, the current study examined body image and eating disturbances in a sample of male gym ...
Peta Stapleton PhD, Timothy McIntyre MPsyc(Clin), Amy Bannatyne MPsyc(Clin)   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A study to determine the effect of the media on the perception of adolescent female body image and the resultant relationship to academic achievement [PDF]

, 2002
Plan BThe purpose of this study was to explore the various issues of body image, and the perceptions that the average adolescent female has about her physical and mental image.
DeLaMater, Jody L.
core