Results 81 to 90 of about 185,748 (298)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Positional information specifies the site of organ regeneration and not tissue maintenance in planarians

eLife, 2018
Most animals undergo homeostatic tissue maintenance, yet those capable of robust regeneration in adulthood use mechanisms significantly overlapping with homeostasis.
Eric M Hill, Christian P Petersen
doaj   +1 more source

Expression of Distal-less, dachshund, and optomotor blind in Neanthes arenaceodentata (Annelida, Nereididae) does not support homology of appendage-forming mechanisms across the Bilateria [PDF]

, 2010
The similarity in the genetic regulation of arthropod and vertebrate appendage formation has been interpreted as the product of a plesiomorphic gene network that was primitively involved in bilaterian appendage development and co-opted to build ...
A Abzhanov, A Caracciolo, A Hejnol, A Hidalgo, A Horner, A Minelli, A Minelli, A Saudemont, A Schmidt-Rhaesa, A Wallberg, AD Chipman, AS Denes, B Hausdorf, B Mittmann, B Prud’homme, B Rhode, C Nielsen, Christopher J. Winchell, CJ Tabin, CJ Winchell, CL Hughes, CM Heuer, CM Heuer, CW Dunn, D Arendt, DA Dorsett, DA Dorsett, David K. Jacobs, DK Jacobs, DK Jacobs, DR Angelini, DR Angelini, DR Maddison, DW Golding, DW Stock, E Abouheif, EC Seaver, EC Seaver, F Ronquist, G Aspöck, G Balavoine, G Campbell, G Giribet, G Mardon, G Panganiban, G Panganiban, G Panganiban, G Scholtz, G Scholtz, G Scholtz, GA Wray, GF Striedter, GO Pflugfelder, GP Wagner, J Felsenstein, J Mallatt, J Mallatt, J Paps, J Paps, JD Thompson, JE Smith, JH Imai, JI Hamaker, JI Pueyo, JJ Gibson-Brown, Jonathan E. Valencia, K Bell, KJ Sepp, KL Hammond, KL Hammond, KS Pappu, L Maves, L Orrhage, L Orrhage, M Kulakova, M Qiu, M Schoppmeier, MJ Bastiani, MJ Telford, N Dray, N Gorfinkiel, N Shubin, N Shubin, N-M Prpic, N-M Prpic, N-M Prpic, N-M Prpic, NJ Strausfeld, NT Takaesu, P Dollé, R Abascal, R Desper, R Janssen, R Janssen, R Kirsch, R Tomer, RF Robledo, RJ Davis, S Candiani, S Guindon, S Nissim, SB Carroll, SF Altschul, SM Cohen, SM Cohen, SM Farris, SQ Irvine, SQ Irvine, SR Martini, T Bartolomaeus, T Kojima, TA Heanue, TA Williams, TH Bullock, W Arthur, W Sewell, W Westheide, WJ Brook, WJ Dickinson, X Yang, Y Boilly-Marer, Y Inoue, Y Inoue, Y Kida, Z Kozmik, Z Kozmik   +125 more
core   +4 more sources

Neural innervation patterns in the sacral vertebral body [PDF]

European Spine Journal, 2015
To characterize the distribution of nerves within a single S1 vertebral body, with particular emphasis on the superior endplate that interfaces with the L5/S1 disc.Musculature and connective tissue surrounding the sacrum was carefully dissected away for close visual inspection of penetrating nerve fibers.
Degmetich, Sean, Bailey, Jeannie F, Liebenberg, Ellen, Lotz, Jeffrey C   +3 more
openaire   +4 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Molecular evolution of HoxA13 and the multiple origins of limbless morphologies in amphibians and reptiles [PDF]

, 2015
Developmental processes and their results, morphological characters, are inherited through transmission of genes regulating development. While there is ample evidence that cis-regulatory elements tend to be modular, with sequence segments dedicated to ...
Bamshad M, Bell MA, Brakefield PM, Brakefield PM, Brayer KJ, Cohn M, Crow KD, Delport W, Di-Poï N, Dollé P, Dollé P, Fromental-Ramain C, Galant R, Gans C, Goodman FR, Gower DJ, Graur D, Günter P. Wagner, Hall BK, Head JJ, Hsieh-Li HM, Innis JW, Knosp WM, Knosp WM, Kobayashi A, Kohlsdorf T, Koryu Kin, Krumlauf R, Lande R, Lynch VJ, Lynch VJ, Mansfield JH, Mariana B. Grizante, Mariana F. Nery, Marina E. Singarete, Mortlock DP, Mortlock DP, Mortlock DP, Murrell B, Parra-Olea G, Pavlicev M, Pavlicev M, Pearson JC, Perez WD, Pyron AR, Pyron RA, Raff RA, Reno PL, Ronshaugen M, San Mauro D, Sarah R. Milograna, Shou S, Sivanantharajah L, Stadler HS, Stern DL, Taylor HS, Thompson JD, Tiana Kohlsdorf, Tschopp P, Warot X, Wiens JJ, Woltering JM, Woltering JM, Wray GA, Yang Z, Yang Z, Zhang J   +66 more
core   +4 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Many Hats of Sonic Hedgehog Signaling in Nervous System Development and Disease. [PDF]

, 2016
Sonic hedgehog (Shh) signaling occurs concurrently with the many processes that constitute nervous system development. Although Shh is mostly known for its proliferative and morphogenic action through its effects on neural stem cells and progenitors, it ...
Belgacem, Yesser H, Borodinsky, Laura N, Hamilton, Andrew M, Shim, Sangwoo, Spencer, Kira A   +4 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Atomically precise lateral modulation of a two-dimensional electron liquid in anatase TiO2 thin films

, 2017
Engineering the electronic band structure of two-dimensional electron liquids (2DELs) confined at the surface or interface of transition metal oxides is key to unlocking their full potential.
Baumberger, F., Bruno, F. Y., Eres, G., Ma, J. -Z., Mesot, J., Patthey, L., Plumb, N. C., Radovic, M., Ricco, S., Ristic, Z., Sangiovanni, G., Shi, M., Walker, S. McKeown, Wang, Z., Zhong, Z.   +14 more
core   +3 more sources