Results 81 to 90 of about 3,364,566 (294)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Patterns of Body and Tail Length and Body Mass in Sciuridae [PDF]

Journal of Mammalogy, 2008
For squirrels, physical size varies with ancestry, locomotion, and sex. Body length has little variation associated with subfamilies or tribes but varies significantly among genera within tribes. Thus, patterns in body size among genera represent more recent evolutionary pressures.
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The planarian dorsal-ventral boundary regulates anterior-posterior axis growth and patterning.

PLoS Biology
Regeneration can involve the coordination of pattern formation in an outgrowth with the spatial pattern of pre-existing tissues, such as along body axes.
Chloe L Maybrun, Isaac M Oderberg, Michael A Gaviño, Thomas F Cooke, Kyungyong Choi, Jongyoon Han, Peter W Reddien   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Hum Genet [PDF]

Classic heterotaxy consists of congenital heart defects with abnormally positioned thoracic and abdominal organs. We aimed to uncover novel, genomic copy-number variants (CNVs) in classic heterotaxy cases.

core  

Extension and patterning of the vertebrate body [PDF]

, 2013
Dissertation presented to obrain the Ph.D degree in Biology. Developmental BiologyVertebrates exhibit an enormous diversity in body shapes. Despite this variability, they all develop by a common principle, in which new tissue is continuously added at ...
Jurberg, Arnon Dias
core  

Expanding the agenda for research on the physically active aging body [PDF]

, 2009
In this article, the authors consider the different approaches that can be used to examine the relationship between physical activity and aging. They propose that much is to be gained in our awareness of this dynamic relationship by drawing on multiple ...
Phoenix, Cassandra, Grant, Bevan C., Phoenix, C., Grant, B., Ra Phoenix, Bevan Grant   +5 more
core   +1 more source

Video4_Archetypal Architecture Construction, Patterning, and Scaling Invariance in a 3D Embryoid Body Differentiation Model.MP4

, 2022
Self-organized patterning and architecture construction studying is a priority goal for fundamental developmental and stem cell biology. To study the spatiotemporal patterning of pluripotent stem cells of different origins, we developed a three ...
Pavel Erokhov (12464580), Olga Gordeeva (12464574), Andrey Gordeev (12464577)   +2 more
core   +1 more source