Results 111 to 120 of about 21,157,326 (340)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Navigating uncertainty in maximum body size in marine metazoans

open access: yesEcology and Evolution
Body size is a fundamental biological trait shaping ecological interactions, evolutionary processes, and our understanding of the structure and dynamics of marine communities on a global scale.
Craig R. McClain   +5 more
doaj   +1 more source

Comparative population genomics analysis for chicken body sizes using genome-wide single nucleotide polymorphisms [PDF]

open access: yesAnimal Bioscience
Objective This study aims to investigate the selection history, genome regions, and candidate genes associated with different chicken body sizes, thereby providing insights into the genetic basis of complex economic traits such as chicken body size and ...
Sensen Yan   +10 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Body size changes in passerine birds introduced to New Zealand from the UK [PDF]

open access: yes, 2013
One feature of global geographic variation in avian body sizes is that they are larger on isolated islands than on continental regions. Therefore, this study aims to assess whether there have been changes in body size following successful establishment ...
Ewen, John   +18 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Cultural influences on body size ideals: unpacking the impact of westernisation and modernisation

open access: yes, 2015
Given that an important component of perceptual body dissatisfaction is the discrepancy between ideal and current body sizes, understanding how body size ideals are shaped and transmitted remains an important task for scholars.
Swami, V.
core   +1 more source

THE DIFFERENTIATION OF SHEEP BREED BASED ON THE BODY MEASUREMENTS [PDF]

open access: yesJournal of the Indonesian Tropical Animal Agriculture, 2011
This research was carried out to make a difference and to predict genetic distance some sheep that are genetically related to each other based on the body size measurements.
E. Handiwirawan   +3 more
doaj  

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

open access: yesNature Materials, 2015
The efficacy of implanted biomedical devices is often compromised by host recognition and subsequent foreign body responses. Here, we demonstrate the role of the geometry of implanted materials on their biocompatibility in vivo.
O. Veiseh   +29 more
semanticscholar   +1 more source

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