Results 91 to 100 of about 998,626 (350)

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Thermoregulation of the newborn: care during the admission in a pediatric emergency UNIT

Rev Rene, 2013
We aimed to investigate the care in thermoregulation of the newborn during the admission in a High Complexity Pediatric Emergency Unit. Retrospective documentary study, carried out ​​in a teaching hospital of Ceará, Brazil.
Aldiania Carlos Balbino, Maria Vera Lúcia Moreira Leitão Cardoso, Ana Luíza Paula de Aguiar Lélis, Fabíola Chaves Fontoura, Gleicia Martins de Melo   +4 more
doaj  

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Does gestation or feeding affect the body temperature of the golden lancehead, Bothrops insularis (Squamata: Viperidae) under field conditions?

Zoologia (Curitiba), 2010
Temperature affects physiological performance in reptiles and, therefore, body temperature (Tb) control is argued to have an important adaptive value.
Rafael P. Bovo, Otavio A. V. Marques, Denis V. Andrade   +2 more
doaj   +1 more source

Genomic and phenotypic signatures of climate adaptation in an Anolis lizard [PDF]

, 2017
Integrated knowledge on phenotype, physiology and genomic adaptations is required to understand the effects of climate on evolution. The functional genomic basis of organismal adaptation to changes in the abiotic environment, its phenotypic consequences,
Hamilton, Rickeisha, Holmes, Leondra, Jordan, Deidra, Rodríguez, Ariel, Rusciano, Tia, Wollenberg Valero, Katharina C.   +5 more
core   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Female thermal sensitivity and behaviour across the lifespan: A unique journey

Experimental Physiology
Women are a group of individuals that undergo unique anatomical, physiological and hormonal changes across the lifespan. For example, consider the impact of the menstrual cycle, pregnancy and menopause, all of which are accompanied by both short‐ and ...
Davide Filingeri, Hannah Blount, Alessandro Valenza   +2 more
doaj   +1 more source

Feeling cold is contagious [PDF]

, 2015
Seeing someone plunge into an ice-cold bath induces feelings of cold. However, it was recently demonstrated that viewing another's skin temperature change also induces a small congruent temperature change in the observer.
Harrison, Neil A
core   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

The impacts of environmental warming on Odonata: a review [PDF]

, 2008
Climate change brings with it unprecedented rates of increase in environmental temperature, which will have major consequences for the earth's flora and fauna.
Adams J., Alcamo J., Angelibert S., Aoki T., Arendt J. D., Askew R. R., Atkinson D., Balmford A., Bendell B. E., Blanckenhorn W. U., Blumenshine S. C., Boehms C., Boothby J., Boothby J., Both C., Braune E., Brown J. H., Burgmer T., Carpenter S. R., Cham S. A., Chang X., Clark T. E., Collingham Y. C., Conrad K. F., Conrad K. F., Coope G. R., Coope G. R., Coope G. R., Corbet P. S., Corbet P. S., Corbet P. S., Corbet P. S., Corbet P. S., Corbet P. S., Corbet P. S., Corbet P. S., Corbet P. S., Cordero Rivera A., Crick H. Q.P., Crowley P. H., Dale M., Danilevskii A. S., Daufresne M., Davis M. B., Dawson T. P., De Block M., De Block M., De Block M., De Block M., Dingemanse N. J., Dorn N. J., Dunn R. R., Eversham B. C., Feuchtmayr H. D., Fitter A. H., Flenner I., Grabow K., Gresens S. E., Hammond C. O., Harada T., Harrington R., Harrington R., Hassall C., Hassall C., Heino J., Henrickson B., Hickling R., Hickling R., Hilfert-Rüppell D., Hill J. K., Hitch A. T., Hostetier S. W., Hunger H., Hynes H. B.N., Ingram B. R., Ingram B. R., Jenner C. E., Johansson F., Johansson F., Karl T. R., Knight T. M., Krishnaraj R., Lawton J. H., Leggott M., Lutz P. E., Lutz P. E., Mann M. E., Masseau M. J., May M. L., May M. L., Meehl G. A., Menetrey N., Merritt R., Michiels N. K., Mooij W. M., Nicholls R. J., Nicholls R. J., Norling U., Norling U., Norling U., Opdam P., Ott J., Ott J., Ott J., Pandey J. P., Parmesan C., Parmesan C., Parmesan C., Pearce-Higgins J. W., Phillips B. L., Pickup J., Piironen J., Pilgrim J. M., Polcyn D. M., Pritchard G., Pritchard G., Pritchard G., Pritchard G., Pritchard G., Pritchard G., Purse B. V., Rantala M. J., Robb T., Robb T., Rolff J., Rouquette J. R., Roy D. B., Sawchyn W. W., Schneider C., Shennan I., Sherratt T. N., Simberloff D., Simmons A. D., Siva-Jothy M. T., Siva-Jothy M. T., Slatkin M., Soluk D. A., Sternberg K., Sternberg K., Sternberg K., Sternberg K., Suhling F., Suhling F., Thompson D. J., Thompson D. J., Thompson D. J., Thompson D. J., Thompson D. J., Travis J. M.J., Valtonen P., Van De Meutter F., Van Doorslaer W., Veron J. E.N., Walther G. R., Waringer J. A., Watanabe M., Watts P. C., Williams D. D., Winder M., Woodward G., Woodward G., Wootton R. J., Xenopoulos M. A., Xenopoulos M. A., Yourth C. P., Zwolsman J. J.G.   +165 more
core   +1 more source