Results 71 to 80 of about 9,351,631 (289)

Functional Changes Induced by Orexin A and Adiponectin on the Sympathetic/Parasympathetic Balance

Frontiers in Physiology, 2018
Obesity and lifestyle-related diseases are major problems faced by people in developed nations. Although exercise training prevents the progression of diabetes and obesity, the motivation for exercise is generally low in obese animals and humans.
Antonietta Messina, Marcellino Monda, Anna Valenzano, Giovanni Messina, Ines Villano, Fiorenzo Moscatelli, Giuseppe Cibelli, Gabriella Marsala, Rita Polito, Maria Ruberto, Marco Carotenuto, Vincenzo Monda, Andrea Viggiano, Aurora Daniele, Ersilia Nigro   +14 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Direct measurement of transcription rates reveals multiple mechanisms for configuration of the Arabidopsis ambient temperature response [PDF]

, 2014
Sensing and responding to ambient temperature is important for controlling growth and development of many organisms, in part by regulating mRNA levels.
Sidaway-Lee, Kate, Costa, Maria J. (Maria João), Steven Penfield, Kate Sidaway-Lee, Sidaway-Lee, K, David A Rand, Penfield, S, Rand, D. A. (David A.), Finkenstädt, Bärbel, Rand, DA, Finkenstädt, B, Penfield, Steven, Bärbel Finkenstadt, Maria J Costa, Costa, Maria   +14 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Increased body temperature following subarachnoid haemorrhage : a retrospective correlational study [PDF]

, 2009
Introduction: Nursing clinicians are primarily responsible for the monitoring and treatment of increased body temperature. The body temperature of patients during their acute care hospital stay is measured at regular repeated intervals. In the event a
Clarke, Samantha A.
core  

Circadian Rhythm of Core Body Temperature (Part II): Hyperbaric Environment Influence on Circadian Rhythm of Core Body Temperature [PDF]

, 2016
The aim of this study was to analyse dynamic fluctuations in the circadian rhythm of the core body temperature in healthy adults exposed to conditions in a hyperbaric chamber, using fully objective-telemetric measurement methods.
Joanna Słomko, Małgorzata Tafil-Klawe, Kozakiewicz, M., Tafil-Klawe, Malgorzata, Siermontowski, Piotr, Klawe, J. J., Tafil-Klawe, M., Klawe, Jacek J, Zalewski, P., Zalewski, Pawel, Jacek J. Klawe, Slomko, Joanna, Mariusz Kozakiewicz, Kozakiewicz, Mariusz, Piotr Siermontowsk, Słomko, J., Paweł Zalewski, Siermontowski, P.   +17 more
core   +1 more source

The Effect of Brief Warming during Induction of General Anesthesia and Warmed Intravenous Fluid on Intraoperative Hypothermia in Patients Undergoing Urologic Surgery

Medicina
Background and Objectives: Transurethral urologic surgeries frequently lead to hypothermia due to bladder irrigation. Prewarming in the preoperative holding area can reduce the risk of hypothermia but disrupts surgical workflow, preventing it from being ...
Ye-Ji Oh, In-Jung Jun
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

A model for the description of feeding regulation by mesozooplankton under different conditions of temperature and prey nutritional status [PDF]

, 2014
Ecosystem modelling studies that consider mesozooplankton feeding regulation have primarily focused on the impact of prey nutritional status and temperature separately, despite experimental evidence for strong links between these two factors.
Acheampong, E., St. John, Michael A., St John, Michael A., Acheampong, Emmanuel, Hense, I., Michael A. St. John, Hense, Inga, Inga Hense, Emmanuel Acheampong, St John, M.   +9 more
core   +1 more source