Results 121 to 130 of about 1,077,986 (305)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Nursing management decisions in fever: a mixed-methods approach to understanding

open access: yesInternational Journal of Nursing Studies Advances
Background: Fever is a common symptom among hospitalized patients and often triggers nursing interventions. Although clinical guidelines recommend the use of antipyretics primarily to alleviate patient discomfort rather than to normalize temperature ...
Lu-Yen A Chen   +3 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

Comparing the effect of once and alternate tepid sponging with Acetaminophen on changes of body temperature of feverish children

open access: yesJournal of Holistic Nursing and Midwifery, 2005
: Introduction: Fever is one of the most common reasons for referring to emergency and clinics (30% of referrals). Primary goal of treating feverish children is to prevent permanent brain and nerve tissue damages.
ezat paryad   +4 more
doaj  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Insulin sensing by astrocytes is critical for normal thermogenesis and body temperature regulation. [PDF]

open access: yesJ Endocrinol, 2020
Manaserh IH   +5 more
europepmc   +1 more source

Validation of the HEN model for organic laying hens and assessment of nutrition in organic poultry (CTE0202) [PDF]

open access: yes, 2005
Introduction Regulation EC1804/1999 sets out the minimum standards for organic livestock production and UK organic poultry producers have to adhere to for organic poultry.
Gordon, S
core  

Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley   +1 more source

Effects of negative energy balance on liver gene and protein expression during the early postpartum period and its impacts on dairy cow fertility [PDF]

open access: yes, 2007
End of project reportNegative energy balance (NEB) is a severe metabolic affecting high yielding dairy cows early post partum with both concurrent and latent negative effects on cow fertility as well as on milk production and cow health.
Diskin, Michael G.   +9 more
core  

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