Results 31 to 40 of about 514,027 (284)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Thermal management of an unconsolidated shallow urban groundwater body [PDF]

, 2013
This study presents the development of tools for the sustainable thermal management of a shallow unconsolidated urban groundwater body in the city of Basel (Switzerland). The concept of the investigations is based on (1) a characterization of the present
F. Händel, J. Epting, Epting, J., Huggenberger, P., P. Huggenberger, Händel, F.   +5 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The effects of age and sex on the body cooling rates. [PDF]

, 1975
PhDWhen the head was cooled for 30 minutes, sublingual temperature fell by as much as 4.45°C below oesophageal which remained steady. Insulation of the head prevented this local cooling.
Sloan, R.E.G.
core  

The lateral habenula contributes to regulation of body temperature

iScience
Summary: The lateral habenula (LHb) is implicated in the regulation of numerous physiological functions, particularly those associated with thermoregulation.
Xuxin Wang, Xiaowei Chen, Zehui Zhang, Xiaofeng Liu, Qianqian Lv, Meiying Song, Danyang Zhao, Jianjun Su, Yana Su, Guoyan Zhao, Jianfeng Sun, Weihong Lin, Hua Zhao   +12 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

To warm up or to pre-cool? The paradox of optimal strategies to undertake prior to exercise in the heat [PDF]

, 2019
© 2009 by Nova Science Publishers, Inc. All rights reserved. Exercise in hot conditions alters the physiological response to the ensuing exercise bout and may hasten the onset of fatigue.
Lovell, R, Duffield, R
core  

Central control of body temperature [version 1; referees: 3 approved]

F1000Research, 2016
Central neural circuits orchestrate the behavioral and autonomic repertoire that maintains body temperature during environmental temperature challenges and alters body temperature during the inflammatory response and behavioral states and in response to ...
Shaun F. Morrison
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source