Results 31 to 40 of about 9,351,631 (289)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The lateral habenula contributes to regulation of body temperature

iScience
Summary: The lateral habenula (LHb) is implicated in the regulation of numerous physiological functions, particularly those associated with thermoregulation.
Xuxin Wang, Xiaowei Chen, Zehui Zhang, Xiaofeng Liu, Qianqian Lv, Meiying Song, Danyang Zhao, Jianjun Su, Yana Su, Guoyan Zhao, Jianfeng Sun, Weihong Lin, Hua Zhao   +12 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Temperature-Dependence of Weibel-Palade Body Exocytosis and Cell Surface Dispersal of von Willebrand Factor and Its Propolypeptide [PDF]

, 2011
Background: Weibel-Palade bodies (WPB) are endothelial cell (EC) specific secretory organelles containing Von Willebrand factor (VWF). The temperature-dependence of Ca2+-driven WPB exocytosis is not known, although indirect evidence suggests that WPB ...
Hewlett, L, Matthew J. Hannah, Carter, T, David Ogden, Hannah, MJ, Matthew J Hannah, Mashanov, G, Gregory Mashanov, Zupančič, G, Knipe, L, Tom Carter, Laura Knipe, Gregor Zupančič, Ogden, D, Lindsay Hewlett, Zupančič Gregor, Hannah, Matthew J., Ogden, David, Hewlett, Lindsay, Carter Tom, Hannah Matthew J., Knipe, Laura, Mashanov, Gregory, Ogden David, Zupančič, Gregor, Hewlett Lindsay, Carter, Tom D., Mashanov Gregory, Knipe Laura   +28 more
core   +1 more source

Central control of body temperature [version 1; referees: 3 approved]

F1000Research, 2016
Central neural circuits orchestrate the behavioral and autonomic repertoire that maintains body temperature during environmental temperature challenges and alters body temperature during the inflammatory response and behavioral states and in response to ...
Shaun F. Morrison
doaj   +1 more source

Regulation of Body Temperature by the Nervous System [PDF]

Neuron, 2018
The regulation of body temperature is one of the most critical functions of the nervous system. Here we review our current understanding of thermoregulation in mammals. We outline the molecules and cells that measure body temperature in the periphery, the neural pathways that communicate this information to the brain, and the central circuits that ...
Tan, Chan Lek, Knight, Zachary A
openaire   +4 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Body orientation for thermoregulation and daily activity cycle of Mabuya macrorhyncha (Squamata: Scincidae)

Zoologia (Curitiba), 2018
We investigated the daily activity and thermoregulatory body orientation of Mabuya macrorhyncha (Hoge, 1947), a lizard species that occurs in the Brazilian Atlantic Forest.
Thiago Maia-Carneiro, Gisele R. Winck, Mariana Rodrigues Pereira, Carlos Frederico Duarte Rocha   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Body temperatures of Manis pentadactyla and Manis javanica

Veterinary Medicine and Science, 2021
Body temperature is an important parameter for assessing animal health and physiological function. An iButton thermometer was used to measure the body temperatures of three Chinese pangolins (Manis pentadacyla) and three Sunda pangolins (M.
Yishuang Yu, Shibao Wu, Wenhua Wang, Amna Mahmood, Fuhua Zhang   +4 more
doaj   +1 more source