Results 41 to 50 of about 514,027 (284)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Accuracy of next‐generation wireless skin temperature sensors during exercise–heat stress
Experimental PhysiologySkin temperature is fundamental in characterising human thermoregulatory responses. Wired probes, although accurate, restrict movement and are impractical outside laboratory settings. The iButton (DS1922L; Maxim Integrated, USA) is a widely used wireless
Aaron J. E. Bach +6 more
doaj +1 more source
Body temperatures of Manis pentadactyla and Manis javanica
Veterinary Medicine and Science, 2021 Body temperature is an important parameter for assessing animal health and physiological function. An iButton thermometer was used to measure the body temperatures of three Chinese pangolins (Manis pentadacyla) and three Sunda pangolins (M.
Yishuang Yu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3 [PDF]
, 2014 Bombesin receptor subtype-3 (BRS-3) regulates energy homeostasis, with Brs3 knockout (Brs3(-/y)) mice being hypometabolic, hypothermic, and hyperphagic and developing obesity.
Reitman, Marc L. +3 more
core +1 more source
Body Temperature Regulation during Heat Stress in the Pregnant Rat [PDF]
, 1974 Body temperature regulation at high ambient temperatures was compared in pregnant and non-pregnant female albino rats. At an ambient temperature of 40ºC, pregnant rats maintained lower body temperatures than non-pregnant rats without added expenditure of
Wilson, Nancy E.
core +3 more sources
Revista da Escola de Enfermagem da USPO presente estudo mostra a problemática da temperatura corporal enquanto um procedimento de enfermagem. Apresenta conceitos relacionados à temperatura e suas alterações, e descreve duas entidades nosológicas relacionadas com a elevação da temperatura ...
Maria Teresa Cícero Laganá +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Central circuitries for body temperature regulation and fever. [PDF]
, 2011 Body temperature regulation is a fundamental homeostatic function that is governed by the central nervous system in homeothermic animals, including humans.
Nakamura, Kazuhiro, Kazuhiro Nakamura
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source