Results 41 to 50 of about 9,351,631 (289)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Accuracy of next‐generation wireless skin temperature sensors during exercise–heat stress
Experimental PhysiologySkin temperature is fundamental in characterising human thermoregulatory responses. Wired probes, although accurate, restrict movement and are impractical outside laboratory settings. The iButton (DS1922L; Maxim Integrated, USA) is a widely used wireless
Aaron J. E. Bach +6 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Body Temperature Regulation During Heat Stress in the Pregnant Rat [PDF]
, 1974 Body temperature regulation at high ambient temperatures was compared in pregnant and non-pregnant female albino rats. At an ambient temperature of 40°C, pregnant rats maintained lower body temperatures than non-pregnant rats without added expenditure ...
Wilson, Nancy E.
core +3 more sources
Revista da Escola de Enfermagem da USPO presente estudo mostra a problemática da temperatura corporal enquanto um procedimento de enfermagem. Apresenta conceitos relacionados à temperatura e suas alterações, e descreve duas entidades nosológicas relacionadas com a elevação da temperatura ...
Maria Teresa Cícero Laganá +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Electricity network regulation in the EU : The challenges ahead for transmission and distribution
, 2018 The UK model of incentive regulation of power grids was at one time the most advanced, and elements of it were adopted throughout the EU. This model worked well, particularly in the context of limited investment and innovation, a single and strong ...
core +1 more source
Physiological ReportsWe evaluated the systemic cardiovascular and carotid baroreflex support of arterial pressure during recovery from whole‐body, passive heating in young and older adults.
Emily A. Larson +7 more
doaj +1 more source