Results 141 to 150 of about 11,463,351 (406)

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

Behavior and weight correlates of weight-control efforts in Australian women living in disadvantage : the READI study [PDF]

, 2013
BackgroundWith increasing obesity rates worldwide, more and more people are actively attempting to lose weight or avoid weight gain, but relatively little is known about what specific behaviors comprise these efforts and which, if any, are associated ...
Abbott, Gavin, Ball, Kylie, Crawford, David, Jeffery, Robert W.   +3 more
core   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Effect of adjunctive ranitidine for antipsychotic-induced weight gain: A systematic review of randomized placebo-controlled trials [PDF]

, 2017
This study was a meta-analysis of randomized controlled trials (RCTs) of ranitidine as an adjunct for antipsychotic-induced weight gain in patients with schizophrenia.
Chen, Rui, Chow, Ines, Golenkov, Andrei, Gu, Xiaojing, Li, Lu, Lok, Grace, Ng, Chee, Sun, Chen-Hui, Ungvari, Gabor S, Wang, Fei, Wang, Shi-Bin, Xiang, Yu-Tao, Yang, Xin-Hu, Zheng, Wei   +13 more
core   +3 more sources

Body Dissatisfaction in Individuals with Obesity Compared to Normal-Weight Individuals: A Systematic Review and Meta-Analysis

Obesity Facts, 2016
Background: Body dissatisfaction has been identified as a psychological correlate of obesity that is related to disordered eating, poor self-esteem, and depression. However, not all individuals with obesity are equally vulnerable to these correlates, and
N. Weinberger, A. Kersting, S. Riedel-Heller, C. Luck-Sikorski   +3 more
semanticscholar   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Height, weight, weight change and risk of breast cancer in Rio de Janeiro, Brazil

São Paulo Medical Journal
CONTEXT: The relationship between body size and breast cancer still remains controversial in considering menopausal status. OBJECTIVE: To evaluate the association of height, weight and weight changes with breast cancer in the city of Rio de Janeiro ...
Anelise Bezerra de Vasconcelos, Gulnar Azevedo e Silva Mendonça, Rosely Sichieri   +2 more
doaj   +1 more source

Use of social networking sites and perception and intentions regarding body weight among adolescents

Obesity Science & Practice, 2016
Summary Objective Social networking sites (SNSs) not only offer users an opportunity to link with others but also allow individuals to compare themselves with other users. However, the link between the use of SNSs and the dissatisfaction with body weight
H. Sampasa‐Kanyinga, J.‐P. Chaput, H. A. Hamilton   +2 more
doaj   +1 more source

Changes in body mass during weight loss treatment – a two-year prospective study

Studia Medyczne, 2017
Introduction : A reduction of 5% to 10% of body mass is related to a significantly lower risk of the occurrence of conditions whose underlying cause is obesity.
Katarzyna Krekora-Wollny, Edyta Suliga
doaj   +1 more source

Ulam Floating Body [PDF]

arXiv, 2018
We study a new construction of bodies from a given convex body in $\mathbb{R}^{n}$ which are isomorphic to (weighted) floating bodies. We establish several properties of this new construction, including its relation to $p$-affine surface areas. We show that these bodies are related to Ulam's long-standing floating body problem which asks whether ...
arxiv