Results 91 to 100 of about 3,320,190 (287)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Economic Factors and Body Weight: An Empirical Analysis [PDF]

With this study, we investigate the effects of changes in economic factors on body weight by constructing a utility theoretic model. The model is empirically estimated by combining data on individuals’ body weight, demographic and physical activity ...
Lusk, Jayson L., Schroeter, Christiane
core   +1 more source

Feed intake and weight and body condition changes of 100% organically fed lactating sows [PDF]

, 2013
Energy and protein density of the 100 % organic lactation diet should be increased as early as from 3rd week of lactation onwards in order to minimize the weight loss of the sow during the at least 40 day lactation period.
Partanen, K., Siljander-Rasi, H., Voutila, L.   +2 more
core  

Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany [PDF]

, 2014
The 12th Stock Conference addressed body composition and related functions in two extreme situations, obesity and cancer cachexia. The concept of ‘functional body composition’ integrates body components into regulatory systems relating the mass of organs
Ahima, Antoun, Arita, Armstrong, Baracos, Barker, Benedict, Berg, Bing, Bing, Bortoluzzi, Bostrom, Boström, Bosy-Westphal, Braun, Canani, Cianfarani, Cole, Compston, Dahlman, De Laet, Delmonico, DiGirolamo, Ding, Drøyvold, Drøyvold, Dulloo, Dulloo, Dulloo, Dulloo, Dulloo, Elkasrawy, Faith, Fearon, Fearon, Fomon, Forbes, Frontera, Gallagher, Godfrey, Goodpaster, Griffith, Hack, Hall, Hall, Hall, Hall, Hall, Hallgreen, Hartwig, Haugen, Heilbronn, Henningsen, Heymsfield, Hotamisligil, Hotamisligil, Hotta, Johannesdottir, Johns, Johnson, Kelley, Keys, Kohrt, Kugel, Lagerpusch, Lagerpusch, Lang, Langlois, Larsen, Later, Leibel, Li, Lieffers, Lieffers, Martin, Montani, Mori, Mracek, Müller, Müller, Müller, Müller, Müller, Müller, Ouchi, Parsons, Pedersen, Pedersen, Pedersen, Perrini, Prado, Prado, Rajala, Raschke, Raschke, Raschke, Ravussin, Rebelos, Rosen, Rosenbaum, Rudolf, Schaap, Schwartz, Shen, Sjöblom, Song, Spalding, Stephens, Stock, Swinburn, Szulc, Sørensen, Sørensen, Taaffe, Trayhurn, Trayhurn, Trayhurn, Trayhurn, Tschöp, Walsh, Wells, Wong, Wu, Yamauchi, Yokota, Yoon, Zampieri, Zhang, Zimmermann   +128 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Association between Weight Change and Incidence of Dyslipidemia in Young Adults: A Retrospective Cohort Study of Korean Male Soldiers

Journal of Obesity & Metabolic Syndrome
Background : Recent lifestyle changes have increased the prevalence of dyslipidemia in Korea. Young men are known to have a low awareness of dyslipidemia and a lack of motivation to maintain their weight.
Joon-Young Yoon, Won Ju Park, Hee Kyung Kim, Ho-Cheol Kang, Cheol-Kyu Park, Wonsuk Choi   +5 more
doaj   +1 more source

Comparative Effectiveness of DPP-4 Inhibitors Versus Sulfonylurea for the Treatment of Type 2 Diabetes in Routine Clinical Practice: A Retrospective Multicenter Real-World Study [PDF]

, 2018
Introduction: DPP-4 inhibitors (DPP4i) and sulfonylureas are popular second-line therapies for type 2 diabetes (T2D), but there is a paucity of real-world studies comparing their effectiveness in routine clinical practice. Methods: This was a multicenter
Avogaro Angelo, Baldi, Ileana, Bossi, Antonio Carlo, Bottigliengo, Daniele, Cavalot, Franco, D'Angelo, Federica, DARWIN-T2D Network, Fadini, Gian Paolo, Morano S., Raffaella Buzzetti, Zatti, Giancarlo   +10 more
core   +1 more source

[Postpartum body weight change].

Ginekologia polska, 1998
To investigate maternal body weight development after pregnancy and to determine the effect of pregravid nutritional status and gestational weight gain on weight change. Design. Prospective cohort study.The population under study consisted of 486 women aged 16-41.
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Changes in body mass during weight loss treatment – a two-year prospective study

Studia Medyczne, 2017
Introduction : A reduction of 5% to 10% of body mass is related to a significantly lower risk of the occurrence of conditions whose underlying cause is obesity.
Katarzyna Krekora-Wollny, Edyta Suliga
doaj   +1 more source