Results 101 to 110 of about 3,943,743 (341)

Real-world data of anamorelin in advanced gastrointestinal cancer patients with cancer cachexia

BMC Palliative Care
Background Cancer cachexia is characterized by the loss of body weight (BW) and anorexia. Anamorelin (ANAM) is a selective ghrelin receptor agonist with appetite-enhancing anabolic action.
Ari Nishimura, Satoshi Hamauchi, Akifumi Notsu, Kunihiro Fushiki, Kotoe Oshima, Takahiro Tsushima, Takeshi Kawakami, Akiko Todaka, Tomoya Yokota, Hirofumi Yasui, Yusuke Onozawa, Kentaro Yamazaki   +11 more
doaj   +1 more source

Effects of protein intake and gender on body composition changes: a randomized clinical weight loss trial

Nutrition & Metabolism, 2012
Limited data on sex differences in body composition changes in response to higher protein diets (PRO) compared to higher carbohydrate diets (CARB) suggest that a PRO diet helps preserve lean mass (LM) in women more so than in men.
Evans Ellen M, Mojtahedi Mina C, Thorpe Matthew P, Valentine Rudy J, Kris-Etherton Penny M, Layman Donald K   +5 more
doaj   +1 more source

Benefits and Risks of Weight-Loss Treatment for Older, Obese Women [PDF]

, 2013
Background: A key issue in the treatment of obesity in older adults is whether the health benefits of weight loss outweigh the potential risks with respect to musculoskeletal injury.
Daniels, Michael J., Middleton, Kathryn R., Milsom, Vanessa A., Perri, Michael G., Rossen, Lauren M.   +4 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Text messaging and brief phone calls for weight loss in overweight and obese English- and Spanish-speaking adults: A 1-year, parallel-group, randomized controlled trial. [PDF]

, 2019
BACKGROUND:Weight loss interventions based solely on text messaging (short message service [SMS]) have been shown to be modestly effective for short periods of time and in some populations, but limited evidence is available for positive longer-term ...
Arredondo, Elva, Crawford, Maggie, Dillon, Lindsay, Godino, Job G, Golaszewski, Natalie M, Griswold, William G, Jain, Sonia, Kolodziejczyk, Julie, Marshall, Simon, Merchant, Gina, Norman, Greg J, Patrick, Kevin, Raab, Fred, Rock, Cheryl L   +13 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Body Contouring After Massive Weight Loss [PDF]

Clinics in Plastic Surgery, 2019
Natalie S. Barton, Al S. Aly, Gregory R. D. Evans   +2 more
openaire   +3 more sources

Superior mesenteric artery syndrome following initiation of cisplatin-containing chemotherapy: a case report

Journal of Medical Case Reports, 2012
Introduction Superior mesenteric artery syndrome is a rare cause of upper intestinal obstruction resulting from compression of the duodenum by the superior mesenteric artery and abdominal aorta. Case presentation We describe a case of superior mesenteric
Ushiki Atsuhito, Koizumi Tomonobu, Yamamoto Hiroshi, Hanaoka Masayuki, Kubo Keishi, Matsushita Mina   +5 more
doaj   +1 more source

Exercise for overweight or obesity [PDF]

, 2006
BACKGROUND: Clinical trials have shown that exercise in adults with overweight or obesity can reduce bodyweight. There has been no quantitative systematic review of this in The Cochrane Library.OBJECTIVES: To assess exercise as a means of achieving ...
Del Mar, C, Gennat, H, O'Rourke, P, Shaw, K   +3 more
core   +1 more source