Results 121 to 130 of about 3,943,743 (341)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Efek posisi penempatan box dan jarak pengangkutan terhadap penyusutan bobot badan dan persentase penyusutan bobot badan pada ayam pedaging finisher

Jurnal Ilmu-Ilmu Peternakan, 2011
The research objective was to study the effect of box position and transportation distance on body weight loss and the percentage of body weight loss on broiler finisher.
Muharlien Muharlien, Achmanu Achmanu, Fani Yulianto   +2 more
doaj  

Current Screening Methods for the Risk or Presence of Malnutrition in Cancer Patients

Cancer Management and Research, 2022
Alessio Molfino, Giovanni Imbimbo, Alessandro Laviano Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, ItalyCorrespondence: Alessandro Laviano, Department of Translational and Precision Medicine, Sapienza University ...
Molfino A, Imbimbo G, Laviano A
doaj  

THE EFFECTIVENESS OF A COMPUTER AND INTERNET-BASED SYSTEM IN A SHORT-TERM BEHAVIORAL WEIGHT LOSS INTERVENTION [PDF]

, 2005
THE EFFECTIVENESS OF A COMPUTER AND INTERNET-BASED SYSTEM IN A SHORT-TERM BEHAVIORAL WEIGHT LOSS INTERVENTIONKristen M. Polzien, PhD.University of Pittsburgh, 2005Computer and Internet-assisted weight loss interventions offer alternative delivery ...
Polzien, Kristen Marie
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study

Nutrition and Healthy Aging, 2018
BACKGROUND: Time restricted feeding decreases energy intake without calorie counting and may be a viable option for weight loss. However, the effect of this diet on body weight in obese subjects has never been examined. OBJECTIVE: This study investigated
K. Gabel, K. Hoddy, Nicole Haggerty, J. Song, C. Kroeger, J. Trepanowski, Satchidananda Panda, K. Varady   +7 more
semanticscholar   +1 more source

Control of Body Weight by Eating Behavior in Children [PDF]

, 2015
Diet, exercise, and pharmacological interventions have limited effects in counteracting the worldwide increase in pediatric body weight. Moreover, the promise that individualized drug design will work to induce weight loss appears to be exaggerated.
Bergh, Cecilia, Esfandiari, Maryam, Ioakimidis, Ioannis, Leon, Michael, Lightman, Stafford, Shield, Julian, Södersten, Per, Zandian, Modjtaba   +7 more
core   +3 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Effects of once‐weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity

Diabetes, obesity and metabolism, 2017
The aim of this trial was to investigate the mechanism of action for body weight loss with semaglutide.
J. Blundell, G. Finlayson, M. Axelsen, A. Flint, C. Gibbons, T. Kvist, J. Hjerpsted   +6 more
semanticscholar   +1 more source